{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:35Z","timestamp":1791925415470,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T00:00:00Z","timestamp":1720396800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dynamic balance assessments such as walking adaptability may yield a more realistic prediction of drug\u2010induced falls compared with postural stability measurements, as falls often result from limited gait adjustments when walking. The Interactive Walkway (IWW) measures walking adaptability but sensitivity to medication effects is unknown. If proven sensitive and specific, IWW could serve as a biomarker for targeted fall\u2010risk assessments in early clinical drug development. In this three\u2010way crossover study, 18 healthy elderly (age: 65\u201380\u2009years) subjects received 5\u2009mg zolpidem, 10\u2009mg suvorexant, or placebo in the morning. Assessments were performed pre\u2010dose and approximately hourly until 9\u2009h post\u2010dose. IWW assessments included an 8\u2010meter walking test, goal\u2010directed stepping, obstacle\u2010avoidance, and tandem\u2010walking. Other pharmacodynamic measurements were the Timed\u2010Up\u2010and\u2010Go (TUG) test at a comfortable and fast pace, adaptive tracking, and body sway. A decline in performance was observed for zolpidem compared with placebo for 3\u2009h post\u2010dose in IWW walking adaptability outcome measures, TUG, adaptive tracking, and body sway. For the IWW tasks, a decrease in walking speed (among others) was observed. IWW parameters were not affected by suvorexant compared with placebo at any timepoint. However, an increase of 9.8% (95%CI: 1.8%, 18.5%) in body sway was observed for suvorexant compared with placebo up to 3\u2009h post\u2010dose. The IWW successfully quantified drug effects of two hypnotic drugs and distinguished between zolpidem and suvorexant regarding their effects on walking. As a biomarker, the IWW demonstrated sensitivity in assessing dynamic balance and potential fall risk in early phase clinical drug development.<\/jats:p>","DOI":"10.1111\/cts.13875","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T05:42:52Z","timestamp":1720503772000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The interactive walkway provides fit\u2010for\u2010purpose fall\u2010risk biomarkers in the elderly: Comparison of zolpidem and suvorexant"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4199-9781","authenticated-orcid":false,"given":"Ingrid","family":"Koopmans","sequence":"first","affiliation":[{"name":"Centre for Human Drug Research  Leiden The Netherlands"},{"name":"Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5277-6607","authenticated-orcid":false,"given":"Daphne","family":"Geerse","sequence":"additional","affiliation":[{"name":"Leiden University Medical Center  Leiden The Netherlands"},{"name":"Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-1124","authenticated-orcid":false,"given":"Melvyn","family":"Roerdink","sequence":"additional","affiliation":[{"name":"Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences Vrije Universiteit Amsterdam, Amsterdam Movement Sciences  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Joanna","family":"Juachon","sequence":"additional","affiliation":[{"name":"Centre for Human Drug Research  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0788-3788","authenticated-orcid":false,"given":"Clemens","family":"Muehlan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology Idorsia Pharmaceuticals Ltd.  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