{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:24:40Z","timestamp":1789575880374,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T00:00:00Z","timestamp":1726531200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Venetoclax, a small molecule inhibitor of BCL\u20102, has demonstrated efficacy in treating acute leukemias and has been recommended as one of the first\u2010line anti\u2010leukemia therapies. Although venetoclax has been suggested to probably possess the ability to penetrate the central nervous system (CNS), current data to elucidate the characteristics of venetoclax in cerebrospinal fluid (CSF), bone marrow (BM), and plasma are still lacking. This study investigated the real\u2010world characteristics of venetoclax concentrations in CSF, BM, and plasma in acute leukemia patients. Thirteen acute leukemia patients treated with venetoclax were included, with paired samples of CSF, BM, and plasma collected and venetoclax concentrations measured using LC\u2013MS\/MS. With the results, the median venetoclax concentrations were 2030\u2009ng\/mL in plasma, 16.7\u2009ng\/mL in CSF, and 1390\u2009ng\/mL in BM. The percentages of CSF\/plasma and BM\/plasma were 0.74% and 70.37%, respectively. While no direct correlation was observed between CSF and plasma venetoclax levels, there was a trend toward an improved CSF\/plasma percentage over time following the last administration of venetoclax. In contrast, a strong correlation was found between BM and plasma levels. This study demonstrated that venetoclax could reach its effective concentration in most patients, suggesting its potential clinical utility in the management of CNS involvement in acute leukemia.<\/jats:p>","DOI":"10.1111\/cts.70006","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T13:41:59Z","timestamp":1726580519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Paired comparisons of venetoclax concentration in cerebrospinal fluid, bone marrow, and plasma in acute leukemia patients"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-415X","authenticated-orcid":false,"given":"Yuan","family":"Jian","sequence":"first","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-5497","authenticated-orcid":false,"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanying","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoling","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Hu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"},{"name":"Chinese Institutes for Medical Research  Beijing 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of central nervous system relapse in acute promyelocytic leukemia by venetoclax: a case report","volume":"11","author":"Zhang X","year":"2021","journal-title":"Front Oncol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-021-04356-5"},{"issue":"7","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.7150\/jca.81795","article-title":"Venetoclax penetrates the blood brain barrier: a pharmacokinetic analysis in pediatric leukemia patients","volume":"14","author":"Badawi M","year":"2023","journal-title":"J Cancer"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2018-0121"},{"key":"e_1_2_9_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1302356","article-title":"Identification of a venetoclax\u2010resistance prognostic signature base on 6\u2010senescence genes and its clinical significance for acute myeloid leukemia","volume":"13","author":"Ke P","year":"2023","journal-title":"Front 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