{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:52:06Z","timestamp":1791417126517,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the United States, 2.0 million new cancer cases and around 600,000 cancer deaths are estimated to occur in 2024. Early detection gives cancer patients the best chance for treatment success. Currently, cancer screening in the general population is recommended for a limited set of cancers; as a result, most cancer types are not regularly screened. Thus, in recent years, we have seen a wave of novel, non\u2010invasive, single\u2010 and multi\u2010cancer detection tests (SCD and MCD), promising detection of cancer signals prior to the onset of symptoms and\/or clinical diagnosis. To accelerate the development, access, and adoption of these tests, the Blood Profiling Atlas in Cancer (BLOODPAC) Consortium, a collaborative infrastructure for developing standards and best practices, established the Early Detection &amp; Screening (ED&amp;S) Working Group. The early detection space is in need of consensus around definitions for SCD and MCD tests that harmonize terminology across diverse stakeholders, thereby reducing communication barriers and ultimately advancing the discipline. To this end, the ED&amp;S Working Group compiled a lexicon of terms, chosen based on perceived importance, frequency of use, lack of clarity, and unique challenges in the context of SCD and MCD tests. This lexicon was submitted to the FDA for their feedback, which was incorporated. In this work, we present the first installment of the lexicon, consisting of 14 primary terms, that will be part of an online dictionary and provide a foundation for future projects of BLOODPAC's ED&amp;S Working Group.<\/jats:p>","DOI":"10.1111\/cts.70016","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T10:11:05Z","timestamp":1724926265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Lexicon for blood\u2010based early detection and screening: BLOODPAC consensus document"],"prefix":"10.1111","volume":"17","author":[{"given":"Christina A.","family":"Clarke","sequence":"first","affiliation":[{"name":"GRAIL  Menlo Park California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breeana L.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Natera  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Putcha","sequence":"additional","affiliation":[{"name":"Precision Medicine &amp; Diagnostics  Los Altos Hills California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Alme","sequence":"additional","affiliation":[{"name":"Guardant Health  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bach","sequence":"additional","affiliation":[{"name":"Delfi  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Beer","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb  Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz M.","family":"Beer","sequence":"additional","affiliation":[{"name":"Exact Sciences  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Beidelschies","sequence":"additional","affiliation":[{"name":"Exact Sciences  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Hoyos","sequence":"additional","affiliation":[{"name":"Prevent Cancer Foundation  Alexandria Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Klein","sequence":"additional","affiliation":[{"name":"GRAIL  Menlo Park California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-4505","authenticated-orcid":false,"given":"Peter","family":"Kuhn","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Krunic","sequence":"additional","affiliation":[{"name":"Novartis  East Hanover New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Lang","sequence":"additional","affiliation":[{"name":"Freenome  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-0952","authenticated-orcid":false,"given":"Jerry S. H.","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1415-3135","authenticated-orcid":false,"given":"Dorys","family":"Lopez\u00a0Ramos","sequence":"additional","affiliation":[{"name":"BLOODPAC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-3947","authenticated-orcid":false,"given":"David","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Delfi  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Quinn","sequence":"additional","affiliation":[{"name":"AstraZeneca  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria M.","family":"Raymond","sequence":"additional","affiliation":[{"name":"Guardant Health  Redwood City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8790-9959","authenticated-orcid":false,"given":"Wendy S.","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"National Institutes of Health\/National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-0281","authenticated-orcid":false,"given":"Stephanie A.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Natera  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Serra","sequence":"additional","affiliation":[{"name":"Quest Diagnostics  Secaucus New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4847-0736","authenticated-orcid":false,"given":"Mark","family":"Stewart","sequence":"additional","affiliation":[{"name":"Friends of Cancer Research  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Leiman","sequence":"additional","affiliation":[{"name":"BLOODPAC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.6238"},{"issue":"22","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1001\/jama.2024.5534","article-title":"Screening for breast cancer: US preventive services task force recommendation statement","volume":"331","author":"US Preventive Services Task Force","year":"2024","journal-title":"JAMA"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1117"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.10897"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2023.107545"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3053ST"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/09691413231174163"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.2172"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107458"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-03960-8"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02048-2"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1158\/2159-8290.CD-23-1492","article-title":"A proposed framework and lexicon for cancer prevention","volume":"14","author":"Castle PE","year":"2024","journal-title":"Cancer Discov"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.666"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2022.2113059"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13427"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33912"},{"key":"e_1_2_9_19_1","unstructured":"National Cancer Institute.NCIthesaurus version: 24.03d. 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