{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:55:27Z","timestamp":1782183327687,"version":"3.54.5"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Higher serum cholesterol levels have been associated with an increased risk of dry eye disease (DED). The relationship between statin (HMG\u2010CoA reductase inhibitor) use and DED in patients with hyperlipidemia remains unclear. To investigate the association between statin use and the risk of DED in patients with hyperlipidemia, we conducted a population\u2010based retrospective cohort study utilizing data from Taiwan's Longitudinal Generation Tracking Database. Patients were categorized into statin users and nonusers, with a 5\u2010year follow\u2010up period. The study identified patients with newly diagnosed hyperlipidemia, excluding those with prior DED diagnoses. Matching and adjustments for covariates resulted in 41,931 individuals in each group. Patients receiving statin therapy were compared with those unexposed. Cumulative exposure doses were also evaluated to assess dose\u2013response relationships. The primary outcome was the incidence of DED diagnosed during the follow\u2010up period. Cox proportional hazards regression models estimated the risk of DED, and conditional logistic regression analyzed the dose\u2013response effect of statin exposure. Among 41,931 matched pairs, statin users exhibited a slightly increased risk of developing DED compared with nonusers (adjusted hazard ratio, 1.06; 95% CI, 1.02\u20131.11; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). However, no dose\u2013response relationship was observed between statin exposure and DED risk. Statin use among patients with hyperlipidemia is associated with a marginally higher risk of DED. These findings underscore the importance of regular eye examinations in this patient population to facilitate early detection and management of DED.<\/jats:p>","DOI":"10.1111\/cts.70039","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T11:10:03Z","timestamp":1727867403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between statin use and dry eye disease in patients with hyperlipidemia: A population\u2010based retrospective cohort study"],"prefix":"10.1111","volume":"17","author":[{"given":"Yong\u2010Wei","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy College of Pharmacy, Taipei Medical University  Taipei City Taiwan"},{"name":"Department of Pharmacy National Taiwan University Cancer Center  Taipei City 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