{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:53:32Z","timestamp":1788274412069,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Polymyxin B is a viable option for treating antibiotic\u2010resistant infections; however, current data on its pharmacokinetics, particularly in patients with renal insufficiency, remain inconclusive and necessitates further investigation. To address this gap, we conducted an open\u2010label, single\u2010center, single\u2010dose, parallel\u2010group pharmacokinetic study. Participants received an intravenous dose of 0.75\u2009mg\/kg of polymyxin B and were categorized based on their renal function: those with normal function (creatinine clearance [CLcr]\u2009\u2265\u200990\u2009mL\/min), mild renal insufficiency (CLcr 60\u201389\u2009mL\/min), and end\u2010stage kidney disease patients on intermittent hemodialysis (IHD) (CLcr\u2009&lt;\u200910\u2009mL\/min). The pharmacokinetic parameters assessed included the area under the curve (AUC), maximum concentration (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ), clearance rate (CL), volume of distribution (Vz), and half\u2010life (\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    ). Results indicated that subjects with mild renal insufficiency exhibited pharmacokinetic profiles similar to healthy individuals. Nevertheless, in patients undergoing long\u2010term IHD, we observed significant differences: the AUC was 58% higher,\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    was 29% lower, CL was 42% lower, Vz was 60% larger, and\n                    <jats:italic>t<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    was extended by 10\u2009h compared to healthy controls. Secondary outcomes revealed good tolerability of polymyxin B across all groups, with no serious adverse effects related to renal function. In summary, while kidney function may have a slight impact on the pharmacokinetic of polymyxin B, it does not compromise the drug's therapeutic effectiveness.\n                  <\/jats:p>","DOI":"10.1111\/cts.70110","type":"journal-article","created":{"date-parts":[[2024,12,14]],"date-time":"2024-12-14T01:48:55Z","timestamp":1734140935000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacokinetic study of polymyxin B in healthy subjects and subjects with renal insufficiency"],"prefix":"10.1111","volume":"17","author":[{"given":"Yu\u2010Wei","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medicine Fu Jen Catholic University  New Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hsien","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Division of Infectious Disease, Department of Internal Medicine Shin\u2010Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsrang\u2010Neng","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Medicine Fu Jen Catholic University  New Taipei City Taiwan"},{"name":"Department of Internal Medicine Shin\u2010Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Sen","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Chest Medicine, Department of Internal Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Ta","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine National Cheng Kung University Hospital, National Cheng Kung University  Tainan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-4689","authenticated-orcid":false,"given":"Ming Hsien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medicine Fu Jen Catholic University  New Taipei City 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