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Based on historical and recent evidences of anti\u2010inflammatory effects of low dose of ionizing radiation, several healthcare professionals proposed low\u2010dose radiation therapy (LDRT) along with ongoing pharmacological treatment for COVID\u201019 pneumonia. A positive response in a few initial studies led to systematic trials by increasing the number of patients in the range of 0.5\u20131.5\u2009Gy. However, the concerns of radiation\u2010induced risks were also raised in parallel. In the present article, we have highlighted the basis of LDRT for COVID\u201019 therapy. We have reviewed the available literature, specifically for outcomes on various clinical trials carried out with LDRT. Meta\u2010analysis was performed to identify if any survival benefits are offered by addition of LDRT over pharmacological treatment alone among COVID\u201019 pneumonia patients. Other clinical recovery parameters such as intubation rates, oxygenation status, anti\u2010inflammatory response have also been compared. Overall data trends favored LDRT with standard pharmacological treatment against control cohort which received standard treatment alone at all the endpoints in majority studies. LDRT addition resulted in significantly higher odds of survival than control cohort. Among critical and\/or mechanically ventilated patients, LDRT did not show any promising outcomes over the control group. In conclusion, LDRT may serve as a promising complementary treatment modality with a potential of better prognosis, provided the patient selection criteria are critically identified and implemented.<\/jats:p>","DOI":"10.1111\/cts.70137","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T07:41:08Z","timestamp":1739346068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Systematic Review and Meta\u2010Analysis of Low Dose Radiation Therapy for <scp>COVID<\/scp>\u201019 Pneumonia: Learnings of 4\u2009Years Since Pandemic"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-0618","authenticated-orcid":false,"given":"Usha","family":"Yadav","sequence":"first","affiliation":[{"name":"Radiological Physics &amp; Advisory Division Bhabha Atomic Research Centre  Trombay, Mumbai India"},{"name":"Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balvinder Kaur","family":"Sapra","sequence":"additional","affiliation":[{"name":"Radiological Physics &amp; Advisory Division Bhabha Atomic Research Centre  Trombay, Mumbai India"},{"name":"Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO \u201cCOVID\u201019 Epidemiological Update \u2013 9 October 2024 \u201d Edition 172 | Emergency Situational Updates (2024) https:\/\/www.who.int\/publications\/m\/item\/covid\u201019\u2010epidemiological\u2010update\u2010edition\u2010172."},{"key":"e_1_2_11_3_1","unstructured":"WHO \u201cCOVID\u201019 Vaccination Insights Report \u2013 4 March 2024 |Meeting Report \u201d (2024) https:\/\/www.who.int\/Publications\/m\/Item\/Covid\u201019\u2010Vaccination\u2010Insights\u2010Report\u20104\u2010March\u20102024."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)00152\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101344"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(22)00045\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(23)00015\u20102"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.11.009"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2867"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000561"},{"key":"e_1_2_11_12_1","volume-title":"WHO\/2019\u2010NCoV\/Therapeutics\/2023.2, Therapeutics and COVID\u201019: Living Guideline, 10 November 2023","author":"WHO\/2019\u2010nCoV\/therapeutics\/2023.2","year":"2023"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)00519\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033825\u20105"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208822"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015017.pub3"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2021.07.035"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.12.028"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2021.12.013"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021436"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201078054\u20102"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2021.100057"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2709.210934"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272042"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081607"},{"issue":"4","key":"e_1_2_11_26_1","first-page":"555","article-title":"How Radiotherapy Was Historically Used to Treat Pneumonia: Could It be Useful Today?","volume":"86","author":"Calabrese E. 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