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While this risk is mainly linked to the decrease in platelet serotonin content, thus abnormal platelet functions, some studies suggest an inherent effect of SSRIs on coagulation. Hence, we performed a literature review to provide an overview of the different studies assessing SSRI's effects on coagulation assays routinely used in clinical practice. A search of the PubMed database yielded 22 relevant studies. Results were inconsistent: While some studies showed minor changes in routine coagulation assays, namely, prothrombin time and activated partial thromboplastin time, the majority found no significant effects of SSRIs on coagulation tests. Then, we specifically investigated the impact of citalopram, a commonly prescribed SSRI, on the thrombin generation assay (TGA) allowing the detection of any potential procoagulant or anticoagulant effect. TGA was performed in platelet\u2010poor plasma from 14 healthy volunteers spiked with citalopram at therapeutic (0.1 and 0.5\u2009\u03bcM) and supratherapeutic (50\u2009\u03bcM) concentrations. TGA parameters were not significantly changed compared to the control condition regardless of the citalopram concentration. All in all, our findings failed to demonstrate any compromised coagulation function associated with SSRI therapy.<\/jats:p>","DOI":"10.1111\/cts.70164","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T05:40:22Z","timestamp":1742362822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Selective Serotonin Reuptake Inhibitors on Coagulation: Fact or Fiction?"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8349-5418","authenticated-orcid":false,"given":"Antoine","family":"Mokhtarian","sequence":"first","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pital Lariboisi\u00e8re, APHP.Nord  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5853-3844","authenticated-orcid":false,"given":"Sophie","family":"Melicine","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pital Lariboisi\u00e8re, APHP.Nord  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6509-8964","authenticated-orcid":false,"given":"Virginie","family":"Siguret","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pital Lariboisi\u00e8re, APHP.Nord  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1144, Optimisation th\u00e9rapeutique en neuropharmacologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8738-5975","authenticated-orcid":false,"given":"Georges","family":"Jourdi","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Biologique H\u00f4pital Lariboisi\u00e8re, APHP.Nord  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, INSERM U1144, Optimisation th\u00e9rapeutique en neuropharmacologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000847"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1734\u20101140(12)70894\u20100"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/abc.2014.0997"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809603001103"},{"key":"e_1_2_9_6_1","first-page":"14","article-title":"Fluoxetine and Hemostatic Function: A Pilot Study","volume":"56","author":"Berk M.","year":"1995","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1002\/(SICI)1099-1557(199808)7:1+<S54::AID-PDS345>3.0.CO;2-Z","article-title":"Study of Haemostasis in Depressive Patients Treated With Fluoxetine: Fluoxetine and Haemostasis","volume":"7","author":"Lain\u00e9\u2010Cessac P.","year":"1998","journal-title":"Pharmacoepidemiology and Drug Safety"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.14744\/tjtes.2020.96892"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v62n0210g"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2011.09.002"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.6.883b"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101819.2011.02241.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0033\u20103182(98)71350\u20107"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C112"},{"key":"e_1_2_9_15_1","first-page":"1070","article-title":"Use of Cytochrome P450 and Prolonged Prothrombin Time","volume":"58","author":"Liu A. 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