{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:24:25Z","timestamp":1792002265430,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The risk of psoriasis in diabetic patients has rarely been explored. This study aims to compare the risk of incident psoriasis in patients with Type 2 diabetes (T2D) who initiate dipeptidyl peptidase\u20104 inhibitors (DPP\u20104is) or thiazolidinediones (TZDs) with those who initiate sulfonylureas, the most common second\u2010line glucose\u2010lowering therapy, in addition to metformin monotherapy. This sequential, propensity\u2010score\u2010matched, new\u2010user comparative effectiveness study utilized a target trial emulation framework. It included adults with T2D receiving metformin monotherapy, using data from 2006 to 2015 from a general population database in Taiwan. The primary outcome was the incidence of psoriasis, determined through diagnoses recorded in urgent care, hospital, and outpatient department records. Cox proportional hazards and Poisson regressions with 1:4 propensity score matching was employed to evaluate the risk factors for psoriasis after adjusting for comorbidities and the use of other medications. In 49,810 propensity score\u2010matched adults with T2D (27,630 men [55.4%]; mean age 57.5\u2009years) identified in the database, the incidence rate of psoriasis in DPP\u20104i users was 188 cases per 100,000 person\u2010years, lower than in sulfonylurea users (467 cases per 100,000 person\u2010years), with a hazard ratio(HR) of 0.422 (95% CI, 0.273\u20130.716). For the TZD vs. sulfonylurea comparison, the HR was 0.35, but the smaller matched dataset resulted in wide confidence intervals. The findings suggest that the use of DPP\u20104is is associated with a lower risk of psoriasis compared to sulfonylureas in patients with T2D. These results can guide the selection of glucose\u2010lowering therapies in T2D patients who are at risk of developing psoriasis.<\/jats:p>","DOI":"10.1111\/cts.70177","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:49:04Z","timestamp":1741841344000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Psoriasis Risk Is Lower in Type 2 Diabetes Patients Using Dipeptidyl Peptidase\u20104 Inhibitors or Thiazolidinediones Compared to Sulfonylureas"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0271-0044","authenticated-orcid":false,"given":"Wei\u2010Sheng","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine Taipei Veterans General Hospital, National Yang\u2010Ming Chiao Tung University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-181X","authenticated-orcid":false,"given":"Tzu\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2622-7524","authenticated-orcid":false,"given":"Yu\u2010Sheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-920X","authenticated-orcid":false,"given":"Yu\u2010Chuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Wang Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1093-6019","authenticated-orcid":false,"given":"Hui\u2010Ching","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Wang Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3571-7760","authenticated-orcid":false,"given":"Tzu\u2010Tung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Biostatistics Center College of Management, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Idaho State University  Pocatello Idaho USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-4125","authenticated-orcid":false,"given":"Jin\u2010Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Biostatistics Center College of Management, Taipei Medical University  Taipei Taiwan"},{"name":"Graduate Institute of Data Science College of Management, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-191X","authenticated-orcid":false,"given":"Chi\u2010Ching","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine College of Medicine, Taipei Medical University  Taipei Taiwan"},{"name":"Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184347"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2019.01.009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcd.2007.10.004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0399-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.09.005"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12886"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/ebmed-2011-100388"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01533-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.042"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333358"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12647"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15196"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-002995"},{"key":"e_1_2_12_15_1","first-page":"157","article-title":"Accuracy of Diabetes Diagnosis in Health Insurance Claims Data in Taiwan","volume":"104","author":"Lin C. C.","year":"2005","journal-title":"Journal of the Formosan Medical Association"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-6646-9_4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-900.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2008.08515.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010008\u20100862\u20101"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700439"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12408"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12955"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000514494"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-205216"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000642"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.028"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1544702"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895\u2010016\u20100049\u2010y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2012.691963"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T06:54:20Z","timestamp":1743317660000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/cts.70177"],"URL":"https:\/\/doi.org\/10.1111\/cts.70177","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70177"}}