{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:31:38Z","timestamp":1787938298349,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Pharmacogenomics research has predominantly focused on populations of European ancestry, limiting the application to diverse populations such as American Indian and Alaska Native (AIAN) communities. Our community\u2010centric study aims to understand perspectives on utilizing pharmacogenomics to guide tobacco cessation in an AIAN community using a survey with qualitative and quantitative components. We assessed participant (<jats:italic>n\u2009=<\/jats:italic>\u2009273) tobacco usage and cessation history, pharmacogenomics knowledge, and perceptions of utilizing pharmacogenomics in the context of tobacco cessation. We found that the majority of participants (92%) were aware of the risks associated with tobacco usage and believed it to be a problem within their community (76%). Our results showed that 29% of participants had some level of knowledge regarding pharmacogenomics and only 6% had previously participated in pharmacogenomics research, demonstrating the need for further education and awareness. Community involvement was a priority for participants, with 64% preferring Tribal inclusion in all research stages and 63% favoring partnerships with local health centers. We also found support for future research, with 68% viewing pharmacogenomics as a beneficial tool. Concerns were raised regarding the handling of genetic material and result dissemination, emphasizing the importance of ethical research practices, transparent communication, and community partnership. Our findings serve as a foundation for shaping future research efforts and developing a framework for implementing tobacco cessation interventions. Our community\u2010centered approach addresses the specific needs of this AIAN community and offers insights applicable to research practices within other underserved and marginalized populations, particularly those with a historical distrust of research.<\/jats:p>","DOI":"10.1111\/cts.70194","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T07:50:14Z","timestamp":1741852214000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Perspectives on Using Pharmacogenomics to Guide Tobacco Cessation: Survey Results From an American Indian Community"],"prefix":"10.1111","volume":"18","author":[{"given":"Madeline L.","family":"Wichman","sequence":"first","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Skaggs School of Pharmacy, University of Montana  Missoula Montana USA"},{"name":"L.S. Skaggs Institute for Health Innovation, University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela M.","family":"Wall","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Skaggs School of Pharmacy, University of Montana  Missoula Montana USA"},{"name":"L.S. Skaggs Institute for Health Innovation, University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanna S.","family":"Garcia Mota","sequence":"additional","affiliation":[{"name":"Environmental Stewardship of Indigenous Lands Certificate Program University of Colorado Denver  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7288-5196","authenticated-orcid":false,"given":"Shayna R.","family":"Killam","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Skaggs School of Pharmacy, University of Montana  Missoula Montana USA"},{"name":"L.S. Skaggs Institute for Health Innovation, University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Skaggs School of Pharmacy, University of Montana  Missoula Montana USA"},{"name":"L.S. Skaggs Institute for Health Innovation, University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaja","family":"Aagaard","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanita","family":"Swaney","sequence":"additional","affiliation":[{"name":"Tribal Health Department Confederated Salish and Kootenai Tribes  St. Ignatius Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LeeAnna I.","family":"Muzquiz","sequence":"additional","affiliation":[{"name":"Tribal Health Department Confederated Salish and Kootenai Tribes  St. Ignatius Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadette N.","family":"Corum","sequence":"additional","affiliation":[{"name":"Tribal Health Department Confederated Salish and Kootenai Tribes  St. Ignatius Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-5018","authenticated-orcid":false,"given":"Katrina G.","family":"Claw","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-4140","authenticated-orcid":false,"given":"Erica L.","family":"Woodahl","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Pharmaceutical Sciences Skaggs School of Pharmacy, University of Montana  Missoula Montana USA"},{"name":"L.S. Skaggs Institute for Health Innovation, University of Montana  Missoula Montana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,13]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cPharmacogenomics General Knowledge Base: PharmGKB.\u201d https:\/\/www.pharmgkb.org\/."},{"key":"e_1_2_9_3_1","unstructured":"Clinical Pharmacogenetics Implementation Consortium: CPIC https:\/\/cpicpgx.org\/."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200409000-00006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2004.10.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32835f834d"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12353"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0000000000000271"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2021.1863948"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0379-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13110"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01672-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14983"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.953142"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283629ce9"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm8010009"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45032-5"},{"key":"e_1_2_9_18_1","first-page":"175","article-title":"Lessons From Havasupai Tribe v. 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