{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:56:01Z","timestamp":1791035761530,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60067"],"award-info":[{"award-number":["2023JJ60067"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To investigate the prevalence, clinical manifestations, and risk factors of hypofibrinogenemia after tigecycline use, which can disrupt coagulation and potentially hinder antimicrobial therapy. This observational study was conducted from January to December 2021 at a tertiary general hospital in China. All patients over 18\u2009years old who received tigecycline for more than 48\u2009h were included. After treatment with tigecycline, patients were divided into two groups based on fibrinogen plasma concentrations of less than 2.0\u2009g\/L. Multivariable logistic regression was performed to identify risk factors for hypofibrinogenemia associated with tigecycline. A total of 50 patients (mean age 71.3\u2009\u00b1\u200920.2\u2009years) were analyzed. The median duration of treatment was 8\u2009days (range: 3 to 20\u2009days). Among the 24 patients who developed hypofibrinogenemia, three gastrointestinal bleeding events were observed, and four of these patients required fibrinogen administration. We identified the total therapeutic dose (odds ratio (OR) =\u200915.28, 95% confidence interval (CI) 2.10\u2013111.02,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and a baseline direct bilirubin level greater than 0.4\u2009mg\/dL (OR\u2009=\u20095.79, 95% CI 1.13\u201327.98,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) as risk factors for tigecycline\u2010induced hypofibrinogenemia. Conversely, a baseline fibrinogen level (OR\u2009=\u20090.53, 95% CI 0.29\u20130.97,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.04) appeared to be a protective factor. Healthcare professionals should be aware that the administration of tigecycline may be associated with hypofibrinogenemia and severe adverse reactions. Regular monitoring of coagulation is essential, particularly for patients with liver dysfunction, low baseline fibrinogen levels, elevated baseline direct bilirubin levels, or those receiving higher total therapeutic doses.\n                  <\/jats:p>","DOI":"10.1111\/cts.70213","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:49:30Z","timestamp":1743727770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Risk Factors and Predictive Indicators for Tigecycline\u2010Associated Hypofibrinogenemia"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-4567","authenticated-orcid":false,"given":"Xiaohui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Nosocomial Infection Management The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine The First Hospital of Changsha(The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatric The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Pediatric The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-7655","authenticated-orcid":false,"given":"Jiheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology &amp; Oncology The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University)  Changsha Hunan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)02724\u20100"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0022\u20103859.48443"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019466"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2022.02.001"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010020\u201004121\u20101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959\u2010024\u201000641\u20104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2018.1452333"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010020\u201001072\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228\u2010020\u201002860\u2010w"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.943674"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010018\u20100694\u20109"},{"key":"e_1_2_10_13_1","unstructured":"Pfizer Incorporated \u201cTygacil (tigecycline) Full Prescribing Information \u201d https:\/\/labeling.pfizer.com\/ShowLabeling.aspx?id=14440. accessed Nov 29 2021."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12431"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw570"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178223419830978"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/23744235.2015.1043942"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2017.0310"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022638"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020084"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01232\u201012"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.07.014"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012467"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.01.006"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2018.01.003"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1713090"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.04.019"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2020.1867783"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112140"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04305\u201014"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.70213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:41:08Z","timestamp":1791034868000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1111\/cts.70213"],"URL":"https:\/\/doi.org\/10.1111\/cts.70213","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70213"}}