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Mixed\u2010effects models can be used for the estimation of variance components from a range of factors (operators, days, reagent lots, etc.) to characterize the \u201cwithin\u2010laboratory\u201d or \u201cacross laboratories\u201d analytical error associated with ADCCs for a variety of samples representing a plethora of measurand intervals. However, this task can be daunting and time\u2010consuming due to the increasing complexity of the number of blood\u2010associated parameters reported by those devices and the iterative calculations over numerous factors. In this paper, we propose a simple\u2010to\u2010follow <jats:italic>R<\/jats:italic> algorithm that overcomes these challenges and provides a comprehensive and effective estimation of variance components in a regulatory\u2010ready reporting format.<\/jats:p>","DOI":"10.1111\/cts.70254","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T02:00:56Z","timestamp":1747965656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Simple Mixed\u2010Effects Modeling for the Precision of Automated Differential Cell Counters Using R"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4889-9233","authenticated-orcid":false,"given":"Karl S. 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