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The primary aim of this systematic review was to summarize antidepressant pharmacogenetic studies to enhance understanding of the genes, variants, datatypes\/methodologies, and outcomes investigated in the context of MDD. The secondary aim was to identify clinical genetic panels indicated for antidepressant prescribing and summarize their genes and variants. Screening of <jats:italic>N<\/jats:italic>\u2009=\u20095793 articles yielded <jats:italic>N<\/jats:italic>\u2009=\u2009390 for inclusion, largely comprising adult (\u2265\u200918\u2009years) populations. Top\u2010studied variants identified in the search were discussed and compared with those represented on the <jats:italic>N<\/jats:italic>\u2009=\u200934 clinical genetic panels that were identified. Summarization of articles revealed sources of heterogeneity across studies and low rates of replicability of pharmacogenetic associations. 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