{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:04:45Z","timestamp":1781175885911,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Degenerative lumbar disease is a significant contributor to acute or chronic musculoskeletal issues in the elderly, often associated with low serum 25\u2010hydroxyvitamin D (25(OH)D) levels. The effect of vitamin D<jats:sub>2<\/jats:sub> supplementation on muscle mass, strength, and physical performance remains unclear. This study aimed to determine the effect of vitamin D<jats:sub>2<\/jats:sub> supplementation on these parameters in patients with degenerative lumbar disease and low vitamin D status. A total of 115 patients with serum 25(OH)D levels &lt;\u200930\u2009ng\/mL were administered 40,000\u2009IU of vitamin D<jats:sub>2<\/jats:sub> (ergocalciferol) weekly for 6\u2009months. Body composition, serum 25(OH)D, parathyroid hormone (PTH) levels, muscle strength, and physical performance were examined before and after 6\u2009months of vitamin D<jats:sub>2<\/jats:sub> supplementation. Baseline median serum 25(OH)D was 24.9\u2009ng\/mL; 79.1% had vitamin D insufficiency, and 20.9% had vitamin D deficiency. After supplementation, median 25(OH)D increased to 43.1\u2009ng\/mL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with a significant reduction in PTH (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Significant improvements were observed in muscle mass (<jats:italic>p<\/jats:italic>\u2009=\u20090.04), balance test (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), gait speed (<jats:italic>p<\/jats:italic>\u2009=\u20090.009), chair stand test (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), short physical performance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), Oswestry disability index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and visual analog scale (VAS) scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post\u2010supplementation 25(OH)D levels correlated negatively with body mass index (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.187, <jats:italic>p<\/jats:italic>\u2009=\u20090.045), fat mass (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.219, <jats:italic>p<\/jats:italic>\u2009=\u20090.019), fat percentage (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.199, <jats:italic>p<\/jats:italic>\u2009=\u20090.033), and VAS score (<jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.313, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Six months of vitamin D<jats:sub>2<\/jats:sub> supplementation significantly improved vitamin D status, muscle mass, physical performance, and quality of life in patients with degenerative lumbar disease.<\/jats:p>","DOI":"10.1111\/cts.70315","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T08:18:38Z","timestamp":1754381918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D Supplementation Improves Muscle Mass, Physical Function, and Quality of Life in Patients With Degenerative Lumbar Disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Sinsuda","family":"Dechsupa","sequence":"first","affiliation":[{"name":"Center of Excellence in Osteoarthritis and Musculoskeleton, Department of Biochemistry, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8784-7604","authenticated-orcid":false,"given":"Wicharn","family":"Yingsakmongkol","sequence":"additional","affiliation":[{"name":"Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopaedics, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worawat","family":"Limthongkul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopaedics, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weerasak","family":"Singhatanadgige","sequence":"additional","affiliation":[{"name":"Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopaedics, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvichada","family":"Assawakosri","sequence":"additional","affiliation":[{"name":"Center of Excellence in Osteoarthritis and Musculoskeleton, Department of Biochemistry, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Pharmacology, Faculty of Science Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-9092","authenticated-orcid":false,"given":"Sittisak","family":"Honsawek","sequence":"additional","affiliation":[{"name":"Center of Excellence in Osteoarthritis and Musculoskeleton, Department of Biochemistry, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0052-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0708097"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aott.2017.03.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-779"},{"key":"e_1_2_11_6_1","first-page":"493","article-title":"Vitamin D Endocrine System and Osteoblasts","volume":"3","author":"Driel M.","year":"2014","journal-title":"Bone Reports"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2728S"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1685"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0437"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4184\/asj.2016.10.5.834"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e318268ff05"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0662-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080799"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2021.46"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.36076\/ppj.2017.1.E99"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2014.10.004"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_11_19_1","first-page":"1417","article-title":"The Oswestry Low Back Pain Disability Questionnaire (Version 1.0) Thai Version","volume":"90","author":"Sanjaroensuttikul N.","year":"2007","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_11_20_1","unstructured":"J.Pattanaphesaj Health\u2010Related Quality of Life Measure (EQ\u20105D\u20105L): Measurement Property Testing and Its Preference\u2010Based Score in Thai Population [Doctoral Dissertation]: Mahidol University(2014)."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2017.02.028"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/953241"},{"key":"e_1_2_11_23_1","first-page":"29","article-title":"Effectiveness of Vitamin D2 Compared With Vitamin D3 Replacement Therapy in a Primary Healthcare Setting: A Retrospective Cohort Study","volume":"2022","author":"Alayed Albarri E. M.","year":"2022","journal-title":"Qatar Medical Journal"},{"key":"e_1_2_11_24_1","first-page":"643","article-title":"Efficacy of High vs. Conventional Ergocalciferol Dose for Increasing 25\u2010Hydroxyvitamin D and Suppressing Parathyroid Hormone Levels in Stage III\u2010IV CKD With Vitamin D Deficiency\/Insufficiency: A Randomized Controlled Trial","volume":"98","author":"Thimachai P.","year":"2015","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.05.026"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2019.06.018"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12172"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00820"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0211OC"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051248"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jfmk6040087"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954422419000064"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T17:20:42Z","timestamp":1755969642000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/cts.70315"],"URL":"https:\/\/doi.org\/10.1111\/cts.70315","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70315"}}