{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:10:28Z","timestamp":1769724628824,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T00:00:00Z","timestamp":1755907200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rebamipide is a gastric mucosal protectant used to relieve gastritis symptoms. Real\u2010world evidence on the comparative effectiveness of rebamipide monotherapy versus combination therapy with proton\u2010pump inhibitors (PPIs) in routine clinical settings is limited. This study evaluated the effect of rebamipide in reducing subjective gastrointestinal (GI) symptoms among patients with gastritis symptoms using a patient\u2010focused approach. This multicenter, observational study enrolled patients aged 19\u2009years and older who were prescribed rebamipide for gastritis symptoms across 81 local clinics and hospitals. Patients received rebamipide twice daily for 2\u2009weeks, with an optional 4\u2010week extension. GI symptom severity and frequency were collected via patient\u2010reported outcomes at baseline and posttreatment. Patients were categorized into a rebamipide monotherapy group and a combination therapy group, with inverse probability of treatment weighting (IPTW) applied to adjust for baseline confounding. Statistical analyses included ANCOVA for symptom score changes and chi\u2010square tests for categorical symptom improvement. Of the 2209 patients included in the analysis, 1946 were in the monotherapy and 263 were in the combination therapy. Both treatment groups showed significant posttreatment reductions in GI symptom scores, and there was no significant difference between the two groups in severity, frequency, and total score before and after IPTW (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). The symptom improvement rate (\u2265\u200950% reduction) was 71.5% in the monotherapy group and 71.4% in the combination therapy group, with no significant difference between the two groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.976). Rebamipide monotherapy provided similar levels of GI symptom relief compared to combination therapy with PPIs in a real\u2010world clinical setting.\n                  <\/jats:p>","DOI":"10.1111\/cts.70327","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T17:39:09Z","timestamp":1755970749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Effectiveness of Rebamipide on Gastritis Symptoms: A Patient\u2010Focused Approach"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0894-2349","authenticated-orcid":false,"given":"Hyun Ji","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Healthcare Engineering, Graduate School Jeonbuk National University  Jeonju Republic of Korea"},{"name":"Nanum Space Co. Ltd  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-2062","authenticated-orcid":false,"given":"Tae\u2010Kyu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Biomedical Engineering, College of Engineering Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-2029","authenticated-orcid":false,"given":"Seol Ju","family":"Moon","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk National University  Jeonju Republic of Korea"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Center for Clinical Pharmacology Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Department of Pharmacology, Medical School Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-9533","authenticated-orcid":false,"given":"Min\u2010Gul","family":"Kim","sequence":"additional","affiliation":[{"name":"Nanum Space Co. Ltd  Jeonju Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University  Jeonju Republic of Korea"},{"name":"Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Center for Clinical Pharmacology Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Department of Pharmacology, Medical School Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2023.38.e115"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1991.tb01467.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2800-9"},{"issue":"9","key":"e_1_2_11_5_1","first-page":"5S","article-title":"Rebamipide: Overview of Its Mechanisms of Action and Efficacy in Mucosal Protection and Ulcer Healing","volume":"43","author":"Arakawa T.","year":"1998","journal-title":"Digestive Diseases and Sciences"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00126839-200304010-00002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2000.0662"},{"issue":"9","key":"e_1_2_11_8_1","first-page":"154S","article-title":"Effect of Rebamipide on Liver Damage and Increased Tumor Necrosis Factor in a Rat Model of Endotoxin Shock","volume":"43","author":"Hong K. W.","year":"1998","journal-title":"Digestive Diseases and Sciences"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S40798"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604183341603"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12769"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1609216"},{"key":"e_1_2_11_13_1","volume-title":"Real\u2010World Data: Assessing Electronic Health Records and Medical Claims Data to Support Regulatory Decision\u2010Making for Drug and Biological Products","author":"FDA","year":"2024"},{"key":"e_1_2_11_14_1","volume-title":"Patient\u2010Focused Drug Development: Collecting Comprehensive and Representative Input","author":"FDA","year":"2018"},{"key":"e_1_2_11_15_1","volume-title":"Patient\u2010Focused Drug Development: Methods to Identify What Is Important to Patients","author":"FDA","year":"2022"},{"key":"e_1_2_11_16_1","volume-title":"Submitting Patient\u2010Reported Outcome Data in Cancer Clinical Trials","author":"FDA","year":"2023"},{"key":"e_1_2_11_17_1","volume-title":"Guidance for Industry: Patient\u2010Reported Outcome Measures","author":"FDA","year":"2009"},{"key":"e_1_2_11_18_1","first-page":"125","article-title":"Single Blinded, Randomized, Active Drug Comparative, Multi\u2010Center Study to Evaluate the Therapeutic Efficacy of Gliptide (R) Tab (Sulglycotide 200 mg) in Gastritis Patients; Phase IV Study","volume":"35","author":"Jeong J.\u2010J.","year":"2007","journal-title":"Korean Journal of Gastrointestinal Endoscopy"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6607"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl20338"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04446.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-0180-z"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.11.1807"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl220457"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.0530"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.203"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2011.11.032"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2016.40.3.240"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S353098"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfab158"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjad015"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70327","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.70327","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:10:14Z","timestamp":1769685014000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,23]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/cts.70327"],"URL":"https:\/\/doi.org\/10.1111\/cts.70327","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,23]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70327"}}