{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T22:09:55Z","timestamp":1769724595325,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tacrolimus is an immunosuppressive agent with difficult dosing due to a narrow therapeutic index and large interpatient pharmacokinetic variability, for which CYP3A5 variation plays a role. Tacrolimus\/\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    pharmacogenetic guidelines exclude liver transplant patients with a donor\/recipient\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    mismatch. We sought to determine the influence of donor vs. recipient\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype early post\u2010transplant and evaluate tacrolimus dosing strategies in liver transplant recipients with various recipient\/donor\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype combinations. This was a single\u2010center, retrospective analysis of 58 prospectively enrolled adult liver transplant patients prescribed tacrolimus post\u2010transplant, with donor and recipient\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype data, which were categorized as recipient expresser (RE) or nonexpresser (RN) and donor expresser (DE) or nonexpresser (DN). Patients were stratified as REDE, REDN, RNDN, or RNDE with comparisons across groups. Prediction error (PE) based on predicted versus actual therapeutic dose was calculated for eight published dosing methods. Donor\/recipient genotype was mismatched in 41% of liver transplant recipients. Weight\u2010adjusted total daily dose for first therapeutic tacrolimus concentration was significantly different across CYP3A5 combinations, with recipient expressors requiring the highest doses (REDE 0.15\u2009mg\/kg\/day, REDN 0.19\u2009mg\/kg\/day, RNDE 0.12\u2009mg\/kg\/day, RNDN 0.09\u2009mg\/kg\/day,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006). Of the eight dosing methods analyzed, two performed with &lt;\u20092% PE overall, and \u2264\u200920% PE for all four genotype combinations: one included recipient genotype only; the other included donor and recipient genotype. Collectively, our findings suggest recipient\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype may be more important than donor genotype in the immediate post\u2010liver transplant period for predicting optimal tacrolimus dosing to achieve therapeutic trough concentrations.\n                  <\/jats:p>","DOI":"10.1111\/cts.70329","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T04:30:34Z","timestamp":1756528234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recipient Versus Donor\n                    <i>CYP3A4\/5<\/i>\n                    Genotypes in Adult Liver Transplant Recipients to Achieve Therapeutic Tacrolimus Concentrations Early Post\u2010Transplant"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8534-872X","authenticated-orcid":false,"given":"Eda","family":"Eken","sequence":"first","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Pharmacogenomics and Precision Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1036-6850","authenticated-orcid":false,"given":"Sergio","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8709-1285","authenticated-orcid":false,"given":"Isabella","family":"Angeli\u2010Pahim","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-2892","authenticated-orcid":false,"given":"Alexandra D.","family":"Ladd","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6809-8361","authenticated-orcid":false,"given":"Curtis","family":"Warren","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-6365","authenticated-orcid":false,"given":"Taimour Y.","family":"Langaee","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Pharmacogenomics and Precision Medicine University of Florida  Gainesville Florida USA"},{"name":"Department of Pharmacotherapeutics and Clinical Research, Taneja College of Pharmacy University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6812-1816","authenticated-orcid":false,"given":"Ali","family":"Zarrinpar","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Florida  Gainesville Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9847-1932","authenticated-orcid":false,"given":"Julie A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy and Translational Research, College of Pharmacy University of Florida  Gainesville Florida USA"},{"name":"Center for Pharmacogenomics and Precision Medicine University of Florida  Gainesville Florida USA"},{"name":"Department of Internal Medicine and Pharmaceutics and Pharmacology, Colleges of Medicine and Pharmacy and Clinical and Translational Science Institute The Ohio State University  Columbus Ohio 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