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Therapeutic drug monitoring data from hematooncological patients treated with linezolid for suspected or proven sepsis were analyzed. A pharmacokinetic population model for linezolid was constructed using a nonlinear mixed\u2010effects modeling approach. Monte Carlo simulations were then used to compare various dosing regimens in terms of PK\/PD target attainment. A total of 197 linezolid serum concentrations obtained from 22 patients were included in the analysis. Patients' age was found to be the most predictive covariate for linezolid pharmacokinetics. In a patient with a median age of 59\u2009years, the volume of distribution and clearance of linezolid were 46.2\u2009L and 12.1\u2009L\/h, respectively. During the first 4\u2009days of therapy, linezolid clearance decreased by 33%. The probability of PK\/PD target attainment increased through the individualization of the dose according to the patient's age, administration of a loading dose, and administration of linezolid via continuous infusion. For this scenario, an easy\u2010to\u2010use nomogram was designed.<\/jats:p>","DOI":"10.1111\/cts.70346","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T10:44:22Z","timestamp":1756982662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Population Pharmacokinetic Model\u2010Based Optimization of Linezolid Dosing in Hematooncological Patients With Suspected or Proven Gram\u2010Positive Sepsis"],"prefix":"10.1111","volume":"18","author":[{"given":"Al\u017eb\u011bta","family":"Zav\u0159elov\u00e1","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine \u2013 Hematology University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Merdita","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"\u017d\u00e1k","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine \u2013 Hematology University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Radocha","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine \u2013 Hematology University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"V\u00ed\u0161ek","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine \u2013 Hematology University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"L\u00e1nsk\u00e1","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine \u2013 Hematology University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Mal\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Diagnostics University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University  Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Mich\u00e1lek","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Resuscitation and Intensive Care Medicine, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Slana\u0159","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-738X","authenticated-orcid":false,"given":"Martin","family":"\u0160\u00edma","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, First Faculty of Medicine Charles University and General University Hospital in Prague  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S164515"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200342150\u201000007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.09.009"},{"key":"e_1_2_9_5_1","unstructured":"SmPC Zyvoxid 2MG\/ML INF SOL\u00a8."},{"issue":"8","key":"e_1_2_9_6_1","first-page":"1136","article-title":"Pharmacokinetics, Metabolism, and Excretion of Linezolid Following an Oral Dose of [(14)C]Linezolid to Healthy Human Subjects","volume":"29","author":"Slatter J. 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