{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T23:24:26Z","timestamp":1766705066998,"version":"3.48.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We assessed the predictive value of MAdCAM\u20101 expression on response to vedolizumab\u00a0in patients with inflammatory bowel disease. This was a retrospective, single\u2010center, cohort study including 109 patients with pretreatment inflammation who completed at least three doses of vedolizumab. We described clinical and endoscopic outcomes of patients based on MAdCAM\u20101 expression. There was no significant difference in MAdCAM\u20101 expression when stratified by histology. Patients in clinical remission at 14\u2009weeks had significantly lower median baseline MAdCAM\u20101 expression (37425.3 vs. 46278.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.015). There was no difference in pretreatment MAdCAM\u20101 expression among patients who later achieved endoscopic or biologic response. In the posttreatment cohort, lower MAdCAM\u20101 expression was associated with an increased likelihood of endoscopic or biologic response (36719.5 vs. 44229.9,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.038). However, posttreatment MAdCAM\u20101 expression did not significantly differ when stratified for clinical remission at 14\u2009weeks. Ultimately, MAdCAM\u20101 immunohistochemistry has limited utility as a predictive biomarker but may provide insights into vedolizumab\u2010associated bowel healing.\n                  <\/jats:p>","DOI":"10.1111\/cts.70422","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T11:06:04Z","timestamp":1763982364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colonic Tissue Expression of\n                    <scp>MAdCAM<\/scp>\n                    \u20101 Is Not Predictive of Vedolizumab Responsiveness in Inflammatory Bowel Disease"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-402X","authenticated-orcid":false,"given":"Nikhil","family":"Reddy","sequence":"first","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-3413","authenticated-orcid":false,"given":"Jeremy A.","family":"Klein","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikita","family":"Thomas","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Micic","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center in the Division of Gastroenterology  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zifeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Rubin","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushila","family":"Dalal","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Christensen","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital, and University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haider I.","family":"Haider","sequence":"additional","affiliation":[{"name":"New York Medical College (NYMC)  Valhalla New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesta","family":"Valuckaite","sequence":"additional","affiliation":[{"name":"Bayer Pharmaceuticals  New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine R.","family":"Meckel","sequence":"additional","affiliation":[{"name":"University of Chicago Section of Gastroenterology  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Bissonnette","sequence":"additional","affiliation":[{"name":"University of Chicago Section of Gastroenterology  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4790-8994","authenticated-orcid":false,"given":"Joel","family":"Pekow","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Disease Center University of Chicago Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.07.003"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjz195"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X16635081"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16060"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535\u2010018\u20101480\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjac182"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjx158"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182802bac"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010020\u201001253\u20108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.10.003"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756284820971214"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy307"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70422","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T23:21:52Z","timestamp":1766704912000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,24]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/cts.70422"],"URL":"https:\/\/doi.org\/10.1111\/cts.70422","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"type":"print","value":"1752-8054"},{"type":"electronic","value":"1752-8062"}],"subject":[],"published":{"date-parts":[[2025,11,24]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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