{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:53:11Z","timestamp":1785779591682,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Poisoning among older adults poses unique challenges due to age\u2010related physiological changes, polypharmacy, and comorbidities. As Thailand transitions to a super\u2010aged society, this study characterizes poisoning patterns in Thai older adults to inform prevention strategies. This retrospective, cross\u2010sectional study analyzed poisoning cases involving patients \u2265\u200960\u2009years reported to the Siriraj Poison Control Center from 2020 to 2023. Data included demographics, comorbidities, exposure characteristics, clinical features, and outcomes. Among 5146 poisoning cases, 682 (13.3%) involved older adults (median age: 68.5\u2009years). Females accounted for 50.4%, and the 60\u201369 age group was most affected (53.8%). Comorbidities, primarily cardiovascular diseases, were present in 58.9% of patients. Most exposures were unintentional (74.6%), with nonpharmaceutical agents (54.2%) slightly exceeding pharmaceuticals (45.8%). Common nonpharmaceutical exposures included venomous animals (15.8%), household products (10.2%), and insecticides or rodenticides (7.4%). The most common scenario for unintentional exposure to nonpharmaceuticals was \u201caccidental ingestion of nonedible substances\u201d (41%). Among pharmaceutical exposures, antipsychotics (12.5%), analgesics (8.4%), and cardiovascular agents (5.3%) were most frequent. Unintentional pharmaceutical poisonings (73%) often resulted from adverse drug reactions or interactions (56.8%) or wrong administration route (20.8%). The proportion of fatal cases declined from 2020 to 2023; however, this trend should be interpreted cautiously due to potential confounding factors. Overall, poisoning in Thai older adults is primarily unintentional and often linked to complex medication use and comorbid conditions. These descriptive findings provide baseline information to support future efforts in medication safety, environmental awareness, and mental health promotion for Thailand's aging population.<\/jats:p>","DOI":"10.1111\/cts.70446","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:41:41Z","timestamp":1768614101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patterns and Outcomes of Poisoning Among Older Adults in Thailand: A Four\u2010Year Retrospective Analysis From the Siriraj Poison Control Center"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7302-7729","authenticated-orcid":false,"given":"Pornchanok","family":"Monkaew","sequence":"first","affiliation":[{"name":"Pharmacy Department Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerisa","family":"Thornsri","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Research and Development Department Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-8793","authenticated-orcid":false,"given":"Pattaraporn","family":"Mekavuthikul","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-1018","authenticated-orcid":false,"given":"Junporn","family":"Kongwatcharapong","sequence":"additional","affiliation":[{"name":"Pharmacy Department Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-98367-9.00008-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010024\u201001466\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102125.2003.02007.x"},{"key":"e_1_2_10_5_1","volume-title":"Medication Safety in Polypharmacy: Technical Report","author":"Integrated Health Services (IHS), Medication without Harm","year":"2019"},{"key":"e_1_2_10_6_1","volume-title":"WHO South\u2010East Asia Regional Strategy on Healthy Ageing 2024\u20132030","author":"WHO\/SEARO","year":"2025"},{"key":"e_1_2_10_7_1","volume-title":"The Act on the Elderly, B.E. 2546 (2003 A.D.)","author":"Department of Older Persons","year":"2003"},{"key":"e_1_2_10_8_1","volume-title":"Situation of the Thai Older Persons 2023","author":"Department of Older Persons","year":"2024"},{"key":"e_1_2_10_9_1","volume-title":"Guidelines for Establishing a Poison Centre","author":"Chemical Safety and Health Unit (CHE)","year":"2020"},{"key":"e_1_2_10_10_1","volume-title":"Global Health Estimates 2021: Deaths by Cause, Age, Sex, by Country and by Region, 2000\u20132021","year":"2024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2024.2412423"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.52389\/ydls.v15ita.734"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650701638982"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.403"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.21608\/efmj.2022.59432.1061"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2022.2116339"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010036048"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hkj2.12051"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010021881"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp050"},{"issue":"5","key":"e_1_2_10_21_1","first-page":"331","article-title":"Reducing the Risk of Adverse Drug Events in Older Adults","volume":"87","author":"Pretorius R. 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