{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:53:11Z","timestamp":1785779591659,"version":"3.56.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Clinical genomics and pharmacogenomics have largely remained separate fields, though some genetic variants have overlapping disease risk and drug implications. However, the extent of this overlap is not well studied. To explore this gap, we cross\u2010referenced genes from the American College of Medical Genetics Secondary Findings v3.2 list with genomic databases and drug labeling to identify gene\u2010phenotype pairs with overlapping clinical genomics and pharmacogenomic implications. We searched GeneReviews and PharmGKB (now called ClinPGx) for each gene\u2010phenotype pair and reviewed the FDALabel database contraindications or warnings. Targeted therapies for specific germline\/somatic variants were excluded. PGx\u2010trained pharmacists and a genetic counselor classified gene\u2010phenotype pairs into three levels: Level 1 (Food and Drug Administration's or guideline\u2010driven recommendations), Level 2 (potential pharmacotherapy implication), and Level 3 (no\/weak interactions). Among 97 gene\u2010phenotype pairs reviewed, 22 (23%) were Level 1, 31 (32%) were Level 2, and 44 (45%) were Level 3. Pharmacotherapy implications included risks inferred by disease pathology (e.g., anticoagulants and hereditary hemorrhagic telangiectasia) and less obvious associations (e.g., Marfan syndrome and fluoroquinolones). Unrecognized medication implications may pose patient safety risks. Greater research, information consolidation and dissemination, and multidisciplinary collaboration among clinical genomics specialists, pharmacogenomic specialists, and other practitioners are essential as genetic testing becomes routine in clinical care.<\/jats:p>","DOI":"10.1111\/cts.70464","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:34:22Z","timestamp":1768293262000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacotherapy Risks in Rare Genetic Diseases: Cross\u2010Referencing\n                    <scp>ACMG<\/scp>\n                    Secondary Findings v3.2 List With Clinical Databases"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2708-2566","authenticated-orcid":false,"given":"Josiah D.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Precision Medicine and Genomic Health St. Elizabeth Healthcare  Edgewood Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-5078","authenticated-orcid":false,"given":"Benjamin Q.","family":"Duong","sequence":"additional","affiliation":[{"name":"Precision Medicine Program Nemours Children's Health  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine and Genomic Health St. Elizabeth Healthcare  Edgewood Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Arn","sequence":"additional","affiliation":[{"name":"Precision Medicine Program Nemours Children's Health  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp2030694"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/CPT.1304"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/CPT.1319"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/CLPT.2014.38"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/AJHP\/ZXAC064"},{"key":"e_1_2_9_7_1","volume-title":"StatPearls","author":"Trujillo R.","year":"2025"},{"key":"e_1_2_9_8_1","volume-title":"STRATTERA Product Monograph PRODUCT MONOGRAPH","author":"Strattera P.","year":"2020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0032"},{"key":"e_1_2_9_10_1","unstructured":"Trulicity (dulaglutide) Package Insert. 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