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In this Perspective, we propose that PK itself functions as a biomarker that bridges dose, exposure, and response. Using examples from target\u2010mediated drug disposition, antidrug antibodies, cerebrospinal fluid PK, high\u2010dose methotrexate therapy, and anti\u2010infective pharmacology, we illustrate how PK serves as a measurable, predictive, and actionable biomarker that informs drug development, guides decisions, and advances precision medicine.<\/jats:p>","DOI":"10.1111\/cts.70486","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T15:42:12Z","timestamp":1769528532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetics as a Biomarker"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0636-5006","authenticated-orcid":false,"given":"John A.","family":"Wagner","sequence":"first","affiliation":[{"name":"Aditum Bio, Tempero Bio, and Trames Bio Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9376-9649","authenticated-orcid":false,"given":"Sonal","family":"Singh","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc. 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