{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:11:01Z","timestamp":1788379861321,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ecopipam is a first\u2010in\u2010class dopamine D1 receptor antagonist under investigation for the treatment of Tourette syndrome. This open\u2010label, fixed\u2010sequence, three\u2010cohort study evaluated whether ecopipam induces or inhibits cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, organic anion\u2010transporting polypeptide (OATP) 1B1, and p\u2010glycoprotein (P\u2010gp). Probe substrates were administered alone and after single or steady\u2010state dosing of ecopipam (1.8\u2009mg\/kg\/day). Cohort 1 received standard doses of omeprazole (CYP2C19), caffeine (CYP1A2), and dextromethorphan (CYP2D6) orally, and a microdose of midazolam (CYP3A4) intravenously. Cohort 2 received a standard dose of bupropion (CYP2B6) orally. Cohort 3 received an oral solution containing microdoses of dabigatran (P\u2010gp), pitavastatin (OATP1B1), rosuvastatin (BCRP, OATP, and P\u2010gp), atorvastatin (BCRP, OATP, P\u2010gp, and CYP3A4), and midazolam. A total of 56 healthy individuals (median [range] age, 36.5 [19\u201354] years; 85.7% male) were enrolled, and 48 completed the study. Ecopipam was well tolerated in the presence and absence of probe substrates. Steady\u2010state ecopipam administration increased dextromethorphan exposure (&gt;\u2009100\u2010fold); decreased the AUC\n                    <jats:sub>inf<\/jats:sub>\n                    of midazolam, omeprazole, and dabigatran by 44.2%, 44.1%, and 37.9%, respectively; and decreased unconjugated bilirubin (UGT1A1) by 19.5%. Single\u2010dose ecopipam increased atorvastatin\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    by 95% and rosuvastatin\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    by 11%, whereas steady\u2010state ecopipam decreased the AUC\n                    <jats:sub>inf<\/jats:sub>\n                    of atorvastatin by 26.8% and rosuvastatin by 16.4%. There were no changes in caffeine, bupropion, or pitavastatin exposure. Ecopipam is a strong inhibitor of CYP2D6 and weak inducer of CYP3A4, CYP2C19, P\u2010gp, and UGT1A1. Ecopipam did not inhibit CYP3A4, CYP2C19, CYP2B6, CYP1A2, UGT1A1, P\u2010gp, or OATP1B1 and did not induce OATP1B1 or CYP2B6.\n                  <\/jats:p>","DOI":"10.1111\/cts.70490","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:25:50Z","timestamp":1770186350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Ecopipam on the Pharmacokinetics of Concomitant Medications"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-2384","authenticated-orcid":false,"given":"Virginia D.","family":"Schmith","sequence":"first","affiliation":[{"name":"Schmith PK\/PD Consulting, LLC and Syntegrity Quantitative Clinical Pharmacology Collaborative  Cocoa Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Graden","sequence":"additional","affiliation":[{"name":"Allucent  Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9716-4711","authenticated-orcid":false,"given":"Lauren L. R.","family":"Lohmer","sequence":"additional","affiliation":[{"name":"Allucent  Cary North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Schleyer","sequence":"additional","affiliation":[{"name":"Emalex Biosciences Inc  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Wanaski","sequence":"additional","affiliation":[{"name":"Paragon Biosciences LLC  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/BEN\u2010120296"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787\u2010016\u20100823\u20108"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00303\u20109"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dhjo.2012.10.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2022\u2010059574"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.70091"},{"issue":"1","key":"e_1_2_10_8_1","article-title":"Presented at: American Society for Clinical Pharmacology & Therapeutics; March 27\u201329 2024; Colorado Springs, CO","volume":"115","author":"Schmith V. 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