{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:22:01Z","timestamp":1792034521866,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inflammation and infection remain unmet challenges in wounds of various etiologies, delaying healing, impacting quality of life, and increasing healthcare costs. The thrombin\u2010derived C\u2010terminal peptide TCP\u201025 has demonstrated dual anti\u2010inflammatory and antibacterial activities in animal wound infection models, thereby promoting healing, highlighting its therapeutic potential as a wound treatment. This first\u2010in\u2010human, double\u2010blind, randomized, within\u2010person and placebo\u2010controlled clinical trial (NCT05378997) evaluated the safety, tolerability, and pharmacokinetics of topical TCP\u201025 in healthy volunteers. Twenty\u2010four participants each received four suction blister wounds (two per thigh), with two wounds treated with TCP\u201025 (either 0.86, 2.9, or 8.6\u2009mg\/mL) and two with placebo gel, 5 times over 8\u2009days. For the primary safety endpoint, no serious or significant adverse events or withdrawals due to adverse events were reported. Twenty\u2010one participants (88%) reported at least 1 adverse event; all were mild or moderate and judged to be unlikely related to TCP\u201025 treatment. No abnormal local reactions occurred and no clinically relevant changes in electrocardiogram, vital signs, laboratory parameters, or physical examination findings were observed between baseline and end of treatment. For the secondary endpoint, TCP\u201025 was undetectable (&lt;\u200990\u2009nmol\/L) in all plasma samples at all timepoints. Thus, topical TCP\u201025 gel was safe and well tolerated by healthy volunteers with epidermal wounds, with no evidence of measurable systemic exposure. Exploratory analyses indicated reduced wound exudation with TCP\u201025 treatment, particularly at 2.9 and 8.6 mg\/mL. Taken together,\u00a0these findings support further clinical evaluation of TCP\u201025 in relevant patient populations.<\/jats:p>","DOI":"10.1111\/cts.70497","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T07:06:57Z","timestamp":1770361617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A First\u2010In\u2010Human Randomized Controlled Phase 1 Study Assessing the Safety and Tolerability of Topical\n                    <scp>TCP<\/scp>\n                    \u201025 Gel in Epidermal Suction Blister Wounds"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-1450","authenticated-orcid":false,"given":"Karl","family":"Wallblom","sequence":"first","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganna","family":"Petruk","sequence":"additional","affiliation":[{"name":"Division of Infection Medicine, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Puthia","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3780-901X","authenticated-orcid":false,"given":"Jane","family":"Fisher","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"Hugerth","sequence":"additional","affiliation":[{"name":"Xinnate AB  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Saleh","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Schmidtchen","sequence":"additional","affiliation":[{"name":"Division of Dermatology and Venereology, Department of Clinical Sciences Lund Lund University  Lund Sweden"},{"name":"Department of Dermatology Skane University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009337"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2005.09.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6932"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2018.10.005"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0210-0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2023.02.016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13922"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15040"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14481"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.020"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14411"},{"key":"e_1_2_10_14_1","volume-title":"Best Practice Guidelines for Skin and Wound Care in Epidermolysis Bullosa. 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