{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:29:53Z","timestamp":1774016993528,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Atopic dermatitis (\n AD<\/jats:styled-content>\n ) is a chronic inflammatory skin disease that markedly impairs quality of life. Janus kinase inhibitors (upadacitinib, abrocitinib, and baricitinib) are effective therapies for moderate\u2010to\u2010severe\n AD<\/jats:styled-content>\n but are associated with viral reactivation, particularly herpes zoster (\n HZ<\/jats:styled-content>\n ), due to immunosuppressive effects on interferon signaling and natural killer cell activity. The objective of this study was to systematically evaluate the risk of\n HZ<\/jats:styled-content>\n among\n AD<\/jats:styled-content>\n patients treated with\n JAK<\/jats:styled-content>\n inhibitors (JAKis), identify key risk factors, and assess the clinical outcomes and management of\n HZ<\/jats:styled-content>\n in this population. A systematic review of\n PubMed<\/jats:styled-content>\n , Embase, and the Cochrane Library evaluated\n HZ<\/jats:styled-content>\n risk in adolescents and adults with moderate\u2010to\u2010severe\n AD<\/jats:styled-content>\n treated with\n JAK<\/jats:styled-content>\n . Searches followed\n PRISMA<\/jats:styled-content>\n guidelines using\n MeSH<\/jats:styled-content>\n and\n EMTREE<\/jats:styled-content>\n terms. The protocol was registered in\n PROSPERO<\/jats:styled-content>\n (\n CRD420251070483<\/jats:styled-content>\n ). Eligible English\u2010language studies included randomized trials, cohort studies, pooled safety analyses, and case series with \u2265\u20095 participants; reviews, case reports, and pediatric, animal, or\n in vitro<\/jats:italic>\n studies were excluded. Data extraction was performed independently by two reviewers. The certainty of evidence was assessed using the\n GRADE<\/jats:styled-content>\n approach. Eleven studies were included. The risk of\n HZ<\/jats:styled-content>\n incidence appears higher in older patients. In some cases, the risk correlates with higher doses of\n JAK<\/jats:styled-content>\n inhibitors, and a trend toward increased\n HZ<\/jats:styled-content>\n events has been observed in Asian populations.\n HZ<\/jats:styled-content>\n is a relevant but generally manageable adverse event in\n AD<\/jats:styled-content>\n patients on\n JAKis<\/jats:styled-content>\n . Risk stratification by age, dose, and comorbidities is advised. Ongoing real\u2010world monitoring is crucial for optimizing outcomes.\n <\/jats:p>","DOI":"10.1111\/cts.70513","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:58:53Z","timestamp":1772989133000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Review of Herpes Zoster Occurrence in Patients With Atopic Dermatitis Treated With\n JAK<\/scp>\n Inhibitors"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1264-9809","authenticated-orcid":false,"given":"Anna","family":"Mandecka","sequence":"first","affiliation":[{"name":"Students Scientific Association at the Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2726-8352","authenticated-orcid":false,"given":"Karolina","family":"Perlak","sequence":"additional","affiliation":[{"name":"Students Scientific Association at the Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6200-2471","authenticated-orcid":false,"given":"Wiktoria","family":"Bajek","sequence":"additional","affiliation":[{"name":"Students Scientific Association at the Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5193-2074","authenticated-orcid":false,"given":"Wiktor","family":"Kruczek","sequence":"additional","affiliation":[{"name":"Students Scientific Association at the Department of Dermatology Medical University of Silesia Katowice Poland"},{"name":"Doctoral School Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-7483","authenticated-orcid":false,"given":"Aleksandra","family":"Fr\u0105tczak","sequence":"additional","affiliation":[{"name":"Chair and Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-5427","authenticated-orcid":false,"given":"Karina","family":"Polak","sequence":"additional","affiliation":[{"name":"Chair and Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-4419","authenticated-orcid":false,"given":"Bartosz","family":"Mizio\u0142ek","sequence":"additional","affiliation":[{"name":"Chair and Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3788-5984","authenticated-orcid":false,"given":"Beata","family":"Bergler\u2010Czop","sequence":"additional","affiliation":[{"name":"Chair and Department of Dermatology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"1171","article-title":"Global Antimicrobial Susceptibility Patterns of Staphylococcus Aureus in Atopic Dermatitis: A Systematic Review and Meta\u2010Analysis","volume":"160","author":"Elizalde\u2010Jim\u00e9nez I. G.","year":"2024","journal-title":"Journal of the American Medical Association"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0001-z"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.10.023"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3514"},{"key":"e_1_2_11_6_1","first-page":"1047","article-title":"Efficacy and Safety of Upadacitinib vs Dupilumab in Adults With Moderate\u2010To\u2010Severe Atopic Dermatitis: A Randomized Clinical Trial","volume":"157","author":"Blauvelt A.","year":"2021","journal-title":"JAMA"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2024.2344591"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0413-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2022.2161812"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00618-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-024-00869-w"},{"issue":"10","key":"e_1_2_11_12_1","article-title":"Herpes Zoster and Venous Thromboembolism Following Upadacitinib Treatment for Severe Atopic Dermatitis","volume":"16","author":"Aoki K. C.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2025.02.040"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00828-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.70125"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-022-02281-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00842-7"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2023.135764"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002735"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18193"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020553"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20887"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14888"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02061"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20936059"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/14397595.2019.1583711"},{"key":"e_1_2_11_28_1","article-title":"Herpes Zoster and Post\u2010Herpetic Neuralgia\u2010Diagnosis, Treatment, and Vaccination Strategies","volume":"2024","author":"Lim D. Z. J.","year":"2024","journal-title":"Pathogens"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70513","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.70513","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:38:07Z","timestamp":1774010287000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/cts.70513"],"URL":"https:\/\/doi.org\/10.1111\/cts.70513","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70513"}}