{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:11:37Z","timestamp":1777957897672,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007693","name":"King Chulalongkorn Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Statin\u2010induced myotoxicity (SIM) is a common adverse effect of simvastatin therapy, which can negatively impact patient adherence and treatment outcomes. This study aims to investigate the impacts of pharmacokinetic (PK) gene polymorphisms on SIM in Thai population treated with simvastatin. One hundred forty\u2010eight Thai participants, including 23 with SIM and 125 tolerant controls were enrolled. The pharmacokinetic genes including,\n                    <jats:italic>ABCB1, ABCC2, ABCG2, SLCO1B1, SLCO1B3, CYP3A4,<\/jats:italic>\n                    and\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    , were genotyped using MassARRAY System. Significant associations were identified for C allele of\n                    <jats:italic>SLCO1B1<\/jats:italic>\n                    rs4149056 (c.521T&gt;C) (OR\u2009=\u20091.9; 95% CI: 1.1\u20133.5;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02) and T allele of\n                    <jats:italic>ABCC2<\/jats:italic>\n                    rs717620 (\u221224C&gt;T) (OR\u2009=\u20092.2; 95% CI\u2009=\u20091.1\u20134.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). Haplotype analysis of\n                    <jats:italic>SLCO1B1<\/jats:italic>\n                    c.521T&gt;C and c.388A&gt;G revealed that the\n                    <jats:italic>*15<\/jats:italic>\n                    haplotype (c.521C and c.388G) was significantly associated with SIM, with a higher frequency in SIM cases (13.0%) compared to controls (6.0%) (OR 2.8; 95% CI\u2009=\u20091.3\u20136.0;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Furthermore, the decreased function phenotype of OATP1B1 (\n                    <jats:italic>SLCO1B1*1b\/*5<\/jats:italic>\n                    or *\n                    <jats:italic>1b\/*15<\/jats:italic>\n                    ), was associated with SIM compared to normal function phenotype. Notably, patients with the decreased function phenotype using simvastatin 20\u201340\u2009mg\/day had a substanstially increase risk of SIM (OR\u2009=\u200910.0; 95% CI\u2009=\u20091.6\u201363.4;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.02). These findings highlight the influence of PK gene polymorphisms on SIM risk and support the importance of genotype\u2010guided simvastatin therapy to minimize adverse effects and improve patient care. Moreover, these also reinforce current CPIC guidelines, which recommend adjusting statins, including simvastatin, therapy based on SLCO1B1 genotype to reduce the risk of myopathy.\n                  <\/jats:p>","DOI":"10.1111\/cts.70528","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:59:46Z","timestamp":1774011586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Pharmacokinetic Gene Polymorphisms on Statin\u2010Induced Myotoxicity in Thai Patients Treated With Simvastatin"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9134-1705","authenticated-orcid":false,"given":"Sayanit","family":"Tipnoppanon","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Faculty of Allied Health Sciences Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarawut","family":"Siwamogsatham","sequence":"additional","affiliation":[{"name":"Division of Hospital and Ambulatory Medicine, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Maha Chakri Sirindhorn Clinical Research Center (Chula CRC), Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkasem","family":"Vorasettakarnkij","sequence":"additional","affiliation":[{"name":"Division of Hospital and Ambulatory Medicine, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology Faculty of Medicine Ramathibodi Hospital, Mahidol University  Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1096-6020","authenticated-orcid":false,"given":"Pajaree","family":"Chariyavilaskul","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Chulalongkorn University  Bangkok Thailand"},{"name":"Department of Pharmacology Faculty of Medicine, Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patompong","family":"Satapornpong","sequence":"additional","affiliation":[{"name":"Division of General Pharmacy Practice, Department of Pharmaceutical Care College of Pharmacy, Rangsit University  Pathum Thani Thailand"},{"name":"Excellence Pharmacogenomics and Precision 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