{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:11:41Z","timestamp":1777957901483,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Renal cell carcinoma (RCC) is a highly heterogeneous malignant neoplasm with multiple morphological and molecular subtypes; however, the basis of this heterogeneity remains incompletely defined, hindering effective diagnosis and treatment. The signaling scaffold IQGAP1 and claudins are tight junction protein partners involved in epithelial cell polarity and polarized secretion whose overexpression has been associated with RCC, though the molecular mechanism is obscure. RNA\u2010seq data on the TCGA database shows that the RNA expression levels of IQGAP1 and claudin\u20102, \u20104, and \u20108 differentially change significantly in normal versus RCC tumors, suggesting a regulatory loop between IQGAP1 and each of these claudins. Previously, we reported that IQGAP1 differentially regulates claudin \u20102 and \u20104 localization and expression at the tight junctions and imparts on kidney epithelial structure and function. Here, we show that IQGAP1 localization, and not mere expression level, accompanies RCC phenotypes and differential expression of several junctional proteins where claudin\u20104 localization remains intact or stabilized. Notably, IQGAP1 expression appears inversely correlated with that of claudin\u20104, supporting a dynamic interaction at the tight junctions. These findings support the notion that IQGAP1 localization influences claudin dynamics, and its dysfunction imparts on RCC. Altogether, these findings pave the way for exploring the differential expression and localization of the IQGAP1\/claudin complex as personalized diagnostics or therapeutics to address RCC heterogeneity.<\/jats:p>","DOI":"10.1111\/cts.70539","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:09:07Z","timestamp":1776262147000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The\n                    <scp>IQGAP1<\/scp>\n                    \u2010Claudin4\u2010\n                    <scp>JNK<\/scp>\n                    Signaling Axis as a Differential Biomarker in Renal Cell Carcinoma"],"prefix":"10.1111","volume":"19","author":[{"given":"Nahshon","family":"Puente","sequence":"first","affiliation":[{"name":"Department of Medicine College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagalakshmi","family":"Nadiminty","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Obi","family":"Ekwenna","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firas G.","family":"Petros","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Sindhwani","sequence":"additional","affiliation":[{"name":"Department of Urology College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Gohara","sequence":"additional","affiliation":[{"name":"Department of Pathology College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Yakirevich","sequence":"additional","affiliation":[{"name":"Department of Pathology Rhode Island Hospital, Brown University Medical School  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-2640","authenticated-orcid":false,"given":"Mahasin A.","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Medicine and Life Sciences, University of Toledo Health Science Campus  Toledo Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.12848"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183809"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-007-9014-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030284"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb05235.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.116"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.08.019"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-017-1112-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15108-y"},{"key":"e_1_2_10_12_1","first-page":"143","article-title":"Epithelial Cell Polarity From the Outside Looking in","volume":"18","author":"Nelson W. 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