{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:11:36Z","timestamp":1777957896939,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The heterogeneity in health effects of circulating proteins remained unclear. Previous studies have identified that glycoprotein acetyls (GlycA), a stable biomarker of inflammation, were associated with risks of mortality and chronic diseases. However, it remained unclear whether the health risks of proteins may differ across people with varied GlycA levels. Based on the multi\u2010omics profiling of the UK Biobank prospective cohort, we evaluated whether GlycA statistically modifies the protein\u2013mortality associations. In the discovery dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924,134), we observed that GlycA significantly modified the associations of ANG, CRHBP, CXCL16, and PRRT3 with all\u2010cause mortality, and these findings were replicated in the validation dataset (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20096081). Subgroup analyses further indicated that associations between these proteins and mortality can be modulated by GlycA levels. Through exploratory analyses focused on chronic diseases and cause\u2010specific mortality, we identified that cross\u2010products of GlycA with these proteins can be associated with cancer mortality and heart failure. Together, the findings will expand our understanding of heterogeneity in protein\u2010health associations and highlight several potential therapeutic targets for interventions across people with varied inflammation status.\n                  <\/jats:p>","DOI":"10.1111\/cts.70542","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:10:43Z","timestamp":1776773443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>GlycA<\/scp>\n                    as an Effect Modifier of Protein\u2013Mortality Associations: A Prospective Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4307-1036","authenticated-orcid":false,"given":"Xinru","family":"Wang","sequence":"first","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Nanjing China"},{"name":"State Key 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Offspring Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-1623","authenticated-orcid":false,"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4085-6796","authenticated-orcid":false,"given":"Qiaoqiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-0292","authenticated-orcid":false,"given":"Yun","family":"Fan","sequence":"additional","affiliation":[{"name":"Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center Nanjing Medical University  Nanjing China"},{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Global Health, School of Public Health Nanjing Medical University  Nanjing China"},{"name":"Key Laboratory of Modern Toxicology of Ministry of Education, School of Public 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