{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:08:42Z","timestamp":1779073722716,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ureteral stent placement following ureteroscopic lithotripsy (URL) reduces obstruction but increases the risk of urinary tract infection (UTI). Conventional antibiotic therapy alone is often insufficient. Ningmitai capsule, a traditional Chinese herbal preparation, has demonstrated anti\u2010inflammatory and antibacterial activity. This study evaluated the efficacy, safety, and translational value of combining Ningmitai with cefoxitin. A retrospective controlled study included 76 patients who developed UTI after URL with stent placement between May 2023 and October 2024. Patients were stratification\u2010matched to a cefoxitin\u2010only group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938, cefoxitin only) or a combined group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200938, cefoxitin plus Ningmitai). Clinical efficacy, urinary symptom scores, inflammatory markers [high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), interleukin\u20101\u03b2 (IL\u20101\u03b2), procalcitonin (PCT)], and adverse reactions were compared. Logistic regression identified independent predictors, and decision curve analysis (DCA) assessed clinical net benefit. The combined group achieved a higher efficacy rate than the cefoxitin\u2010only group (94.74% vs. 78.95%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042). Dysuria, urinary frequency, hematuria, and renal colic improved more significantly, and hs\u2010CRP, IL\u20101\u03b2, and PCT levels decreased to a greater extent in the combined group (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Combination therapy was an independent predictor of success (OR\u2009=\u20094.52, 95% CI: 1.56\u201313.06). The predictive model improved AUC from 0.71 to 0.91. DCA showed superior net benefit between 0.1\u20130.5 thresholds. Adverse events were rare and comparable between groups. Ningmitai capsule combined with cefoxitin improves symptoms, reduces inflammation, and maintains safety in stent\u2010associated UTI after URL. Predictive modeling and DCA confirm its translational potential as an integrative therapeutic approach.\n                  <\/jats:p>","DOI":"10.1111\/cts.70553","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T17:00:08Z","timestamp":1778346008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Use of Ningmitai Capsule and Cefoxitin in Treating Post\u2010Ureteroscopic Lithotripsy Stent\u2010Related Urinary Tract Infections"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5197-2707","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Surgery Taicang Hospital of Traditional Chinese Medicine  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2892-0179","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Surgery Taicang Hospital of Traditional Chinese Medicine  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000001345"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013445.pub2"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13885"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/med\u20102023\u20100854"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2023.151468"},{"key":"e_1_2_13_7_1","first-page":"634","article-title":"Clinical Characteristics of Postoperative Febrile Urinary Tract Infections After Ureteroscopic Lithotripsy in Diabetics: Impact of Glycemic Control","volume":"73","author":"Kazan H. O.","year":"2020","journal-title":"Archivos Espa\u00f1oles de Urolog\u00eda"},{"key":"e_1_2_13_8_1","first-page":"503","article-title":"Predictive Risk Factors of Urinary Tract Infection Following Flexible Ureteroscopic Lithotripsy","volume":"74","author":"Cakici M. C.","year":"2021","journal-title":"Archivos Espa\u00f1oles de Urolog\u00eda"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.03.035"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526522666220928115043"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0359"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.014"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.53738\/REVMED.2020.16.710.1906"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1483864"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/sexmed\/qfaf024"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20220328.502"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0529\u20105815.2018.10.015"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5847806"},{"key":"e_1_2_13_19_1","first-page":"553","article-title":"Inhibitory Effect of Ningmitai Capsules on the Proliferation and Biofilm Formation of Staphylococcus sp. and \n                     Escherichia coli","volume":"26","author":"Chen X.","year":"2020","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.949316"},{"key":"e_1_2_13_21_1","first-page":"249","article-title":"Efficacy and Adverse Effects of Ningmitai Capsules Combined With Antibiotics in the Treatment of Chronic Prostatitis: A Meta\u2010Analysis","volume":"27","author":"Wu P.","year":"2021","journal-title":"Zhonghua Nan Ke Xue"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.2018.0126"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2019.8252"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232113272"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcm.2018.04.001"},{"key":"e_1_2_13_26_1","first-page":"933","article-title":"Ningmitai Capsule for the Treatment of Andrological Diseases: Advances in Studies","volume":"23","author":"Cai H. 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