{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:08:18Z","timestamp":1779073698391,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Orthostatic hypotension (OH) represents a cardinal non\u2010motor manifestation in Parkinson's disease (PD), yet the clinical relevance of its subtypes remains unclear. This study aimed to characterize the clinical and blood pressure (BP) profiles of PD\u2010OH and its subtypes. We enrolled 186 PD patients, including 59 with OH, and collected clinical, postural BP, autonomic, cognitive, emotional, sleep, and REM sleep behavior disorder (RBD) data. Analyses used\n                    <jats:italic>t<\/jats:italic>\n                    \u2010tests, nonparametric tests, and chi\u2010square tests as appropriate. Compared to PD\u2010nOH, PD\u2010OH patients had later onset, higher RBD prevalence, poorer visuospatial function, and better subjective sleep quality. They exhibited lower systolic\/diastolic BP (SBP\/DBP) and larger orthostatic drops across postures. Within PD\u2010OH, diastolic OH with greater cognitive impairment and specific sleep alterations, while symptomatic with worse motor and autonomic function. RBD was linked to greater autonomic dysfunction; depressive symptoms specifically distinguished PD\u2010OH\u2010RBD, whereas cognitive differences distinguished PD\u2010RBD. Advanced PD\u2010OH showed lower SBP\/DBP, especially when seated and immediately after standing. In conclusion, D\u2010OH and symptomatic OH are associated with more severe non\u2010motor symptoms, with cognitive and depressive profiles helping distinguish the interaction of PD, OH, and RBD.\n                  <\/jats:p>","DOI":"10.1111\/cts.70557","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:10:54Z","timestamp":1777435854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Revealing Non\u2010Motor Symptom Profiles of Orthostatic Hypotension Subtypes in Parkinson's Disease: Insights From a Multidimensional Case\u2013Control Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-5387","authenticated-orcid":false,"given":"Zihan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurology The Affiliated Hospital of Qingdao University  Qingdao 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