{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:11:36Z","timestamp":1777957896974,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The utility of heart\u2010type fatty acid binding protein (H\u2010FABP) as a prognostic biomarker in light chain cardiac amyloidosis (AL\u2010CA) patients remains unestablished. Consecutive patients diagnosed with AL\u2010CA in the Heart Failure Center; Fuwai Hospital were enrolled. Baseline H\u2010FABP levels categorized patients as low (\u2264\u20099.5\u2009ng\/mL) or high (&gt;\u20099.5\u2009ng\/mL) group. Kaplan\u2013Meier analysis and Cox proportional hazards models were performed. Model performance was assessed using Harrell's C concordance index (C\u2010index), integrated discrimination improvement (IDI) index, and net reclassification improvement (NRI) index. Eighty\u2010four patients were included (mean age 60.12\u2009\u00b1\u200911.25\u2009years; 32.1% female), with 30 (35.7%) in the high H\u2010FABP group. Overall survival was significantly lower in the high H\u2010FABP group. In multivariable Cox models adjusted for age, eGFR and chemotherapy, H\u2010FABP &gt;\u20099.5\u2009ng\/mL remained independently associated with an increased risk of all\u2010cause mortality when incorporating either the European modified Mayo 2004 stages [adjusted hazard ratio (HR): 2.79, 95% confidence interval (CI): 1.49\u20135.22;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001] or the revised Mayo 2012 stages (HR: 2.67, 95% CI: 1.48\u20134.83;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001). Adding H\u2010FABP levels significantly improved predictive performance across both baseline staging systems. For the European modified Mayo 2004 stage, the C\u2010index increased from 0.622 to 0.663, accompanied by positive IDI (0.053) and NRI (0.294). Similarly, for the revised Mayo 2012 stage, the C\u2010index increased from 0.611 to 0.660, with positive IDI (0.074) and NRI (0.308). Elevation of H\u2010FABP is associated with an increased risk of all\u2010cause mortality in patients with AL\u2010CA. It provides significant additive prognostic value to the established staging system for prognosis in AL\u2010CA.\n                  <\/jats:p>","DOI":"10.1111\/cts.70559","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:56:02Z","timestamp":1776426962000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incremental Prognostic Value of Heart\u2010Type Fatty Acid Binding Protein in Patients With Light Chain Cardiac Amyloidosis: A Prospective Cohort Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4768-3079","authenticated-orcid":false,"given":"Xinqing","family":"Li","sequence":"first","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0309-7288","authenticated-orcid":false,"given":"Anran","family":"Xin","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4971-4824","authenticated-orcid":false,"given":"Guo","family":"Ai","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Liu","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; Peking Union Medical College (CAMS &amp; PUMC)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7477-5712","authenticated-orcid":false,"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Heart Failure Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences &amp; 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