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While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their utility in routine monitoring and clinical trials. Blood\u2010based biomarkers offer a complementary approach, providing minimally invasive, readily accessible measures that can be repeatedly sampled over time. Emerging blood\u2010derived signatures, including gene expression profiles and circulating molecular inflammation scores, capture systemic immune activity and have shown promise in predicting treatment response, disease flares, and pharmacodynamic (PD) effects of therapies. Recent advances utilizing multi\u2010omics technologies and machine learning methods have further improved the predictive performance of blood\u2010based biomarkers, particularly in the context of biologic therapies such as anti\u2013tumor necrosis factor agents. Despite these advances and growing promises, challenges related to validation, standardization, and clinical integration persist. This review focused on recent advances in blood\u2010based biomarkers for IBD, with an emphasis on their use in predicting treatment response and assessing pharmacodynamic effects in clinical trials.<\/jats:p>","DOI":"10.1111\/cts.70562","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:20:22Z","timestamp":1777346422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing\n                    <scp>IBD<\/scp>\n                    Management: A Literature Review on the Role of Non\u2010Invasive Blood\u2010Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5503-7330","authenticated-orcid":false,"given":"Mohamed","family":"Hassanein","sequence":"first","affiliation":[{"name":"Translational and Clinical Biomarkers, Pfizer Inc.  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