{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:47:15Z","timestamp":1782107235968,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    genetic polymorphisms impact the antiplatelet effect of clopidogrel and associate with ischemic and bleeding risk in patients undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the association of\n                    <jats:italic>CYP2C19<\/jats:italic>\n                    and platelet reactivity (PR) with these risks, in atrial fibrillation (AF) patients undergoing PCI,\u00a0treated with an oral anticoagulation (OAC) and clopidogrel. This two\u2010center prospective cohort study included patients with AF and OAC undergoing PCI. Carriers of \u2265\u20091 loss\u2010of\u2010function (LOF) allele were classified as poor\/intermediate metabolizers (PM\/IM), whereas carriers of \u2265\u20091 gain\u2010of\u2010function allele without LOF alleles were classified as rapid metabolizers (RM). PR was assessed by thromboelastography (TEG) and\/or multiple electrode aggregometry (MEA). The primary outcome included death, MI, or stroke at 6\u2009months \u00b12\u2009weeks; the secondary outcome consisted of non\u2010major clinically relevant (NMCR) or major bleeding. Among 283 patients (median age 78\u2009years; 72% male), 73 (26%) were PM\/IM, 108 (38%) were NM, and 102 (36%) were RM. PM\/IM status was not significantly associated with the primary ischemic outcome (PM\/IM: 6 [8.2%] vs. NM\u2009+\u2009RM: 16 [7.6%],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.869), but any bleeding rates were numerically lower. While there was a trend for association of high platelet reactivity (HPR) with the ischemic outcome (OR 2.005 [95% CI 0.820\u20134.902],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.127), low platelet reactivity (LPR) was associated with major bleeding (OR 2.646 [95% CI 1.075\u20136.509],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.034). PM\/IM status did not detect an increased ischemic risk but might, however, protect from bleeding risk in AF patients undergoing PCI. HPR might indicate a higher ischemic risk, while LPR was associated with major bleeding.\n                  <\/jats:p>","DOI":"10.1111\/cts.70598","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:51:16Z","timestamp":1779198676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CYP2C19<\/scp>\n                    Polymorphism and Platelet Aggregation\u2010Associated Risks in Atrial Fibrillation Patients Undergoing\n                    <scp>PCI<\/scp>"],"prefix":"10.1111","volume":"19","author":[{"given":"Diona","family":"Gjermeni","sequence":"first","affiliation":[{"name":"Department of Cardiology and Angiology, University Heart Center Freiburg\u2014Bad Krozingen, Faculty of Medicine University of Freiburg  Freiburg 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