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One approach to enhanced personalization of therapy is the identification of biomarkers for disease phenotype, severity, progression, and response to therapy. To date, several biomarkers have been developed for patients with respiratory diseases, and increasingly, blood\u2010derived protein and peptide biomarkers are under investigation for their potential to achieve better control over respiratory diseases by stratifying patients for specific treatment regimens. However, identifying and quantifying these biomarkers in a routine setup is challenging because of the invasiveness involved in sample collection, the need for in\u2010person clinical visits, and the need for skilled phlebotomy. Consequently, clinical biomarker measurements represent a single\u2010time point indication of health on the day of attendance at a clinic and not necessarily an accurate longitudinal representation of the patient's condition. Micro\u2010sampling techniques have developed the concept of patient\u2010centric sampling with minimal invasiveness, with the goal of the patient taking their own blood sample in micro volumes that are sent for analysis in a centralized laboratory, all from the comfort of their home. While novel micro\u2010sampling techniques have demonstrated promising results in quantifying drugs and proteins from blood, there is limited exploration within the domain of respiratory diseases' biomarkers. Hence, this article provides insights into novel respiratory biomarkers and a future that exploits micro\u2010sampling tools in care pathways to optimize and individualize therapy for patients.<\/jats:p>","DOI":"10.1111\/cts.70600","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T10:56:45Z","timestamp":1780311405000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Respiratory Biomarkers: An Opportunity for Patient\u2010Centric Microsampling Approach for Treatment Optimization"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-0798","authenticated-orcid":false,"given":"Ahmar","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Medicine, Applied and Clinical Sciences, School of Health, Medicine, and Life Sciences University of Hertfordshire  Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8365-5894","authenticated-orcid":false,"given":"Jacqueline L.","family":"Stair","sequence":"additional","affiliation":[{"name":"Department of Medicine, Applied and Clinical Sciences, School of Health, Medicine, and Life Sciences University of Hertfordshire  Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9235-0053","authenticated-orcid":false,"given":"Daniel","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Applied and Clinical Sciences, School of Health, Medicine, and Life Sciences University of Hertfordshire  Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-2479","authenticated-orcid":false,"given":"Neil","family":"Spooner","sequence":"additional","affiliation":[{"name":"Spooner Bioanalytical Solutions  Hertford Hertfordshire UK"},{"name":"Patient Centric Sampling Interest Group CIC  Ware Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4364-7491","authenticated-orcid":false,"given":"Darragh","family":"Murnane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Applied and Clinical Sciences, School of Health, Medicine, and Life Sciences University of Hertfordshire  Hatfield Hertfordshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"BEST (Biomarkers, EndpointS, and Other Tools) Resource","author":"FDA\u2010NIH Biomarker Working Group","year":"2016"},{"key":"e_1_2_10_3_1","volume-title":"Asthma: Diagnosis, Monitoring and Chronic Asthma Management (BTS, NICE, SIGN)","author":"NICE BS","year":"2024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/25310429.2025.2563445"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ansa.202300011"},{"key":"e_1_2_10_6_1","unstructured":"Patient centric sampling interest group \u201cEnabling Patients to Take Control of Sampling \u201dhttps:\/\/www.pcsig.org\/what\u2010is\u2010patient\u2010centric\u2010sampling."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931\u2010025\u201003356\u2010w"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.ijp_970_24"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12196125"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0329\u20102019"},{"key":"e_1_2_10_11_1","unstructured":"GOLD \u201c2024 GOLD Report \u201d(2024)."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2024.12.010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2022.01.010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1693114"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/photonics12090848"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5858\/132.12.1916"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010022\u201000999\u20108"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17576180.2025.2572289"},{"key":"e_1_2_10_19_1","first-page":"673","volume-title":"Biomarkers of Pulmonary Diseases. 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