{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T05:47:04Z","timestamp":1782107224155,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Maintenance fluids for neonates, which are commonly composed of glucose 10%, sodium chloride (NaCl) 0.225% w\/v with potassium chloride (KCl) 20\u2009mmol\/L (GSP), are administered as a continuous infusion, and prescribed medications are required to be co\u2010administered frequently through a Y\u2010site. There are limited studies on the compatibility of commonly used medicines with this maintenance fluid. Therefore, the objective of this study is to study the compatibility of commonly used medicines in the neonatal intensive care unit with maintenance fluid (GSP). An audit at the RCH Neonatal Intensive Care Unit (NICU) was performed to determine the average doses, durations of infusion, and volumes of maintenance fluid, benzylpenicillin, and calcium gluconate administered. The Y\u2010site chemical compatibility of calcium gluconate with the GSP was determined using a titration method. The Y\u2010site physical compatibility for both calcium gluconate and benzylpenicillin with the GSP was determined on the basis of visual appearance, turbidity, and pH. There was no clinically significant change in pH, turbidity, or concentration of the calcium gluconate at a 1:1, 1:2, 1:4, or 2:1 ratio with GSP with a contact time of up to 4\u2009hours. Both physical and chemical analyses demonstrated the stability of calcium gluconate with GSP at a range of concentrations and time points, indicating Y\u2010site compatibility. Physical changes were detected in the samples containing benzylpenicillin and GSP following the longer interaction time, thus indicating potential Y\u2010site incompatibility. This has been confirmed by both the turbidity and the Z\u2010average tests.<\/jats:p>","DOI":"10.1111\/cts.70603","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:48:27Z","timestamp":1779418107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Simulated Y\u2010Site Compatibility of Calcium Gluconate and Benzylpenicillin With Maintenance Fluid Used in Neonatal Intensive Care Unit"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-8077","authenticated-orcid":false,"given":"Ayman","family":"Allahham","sequence":"first","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Pulbrook","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-4394","authenticated-orcid":false,"given":"Billy","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Food Technology &amp; Nutrition, School of Science, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Halliwell","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhan","family":"Le","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Wong","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viena","family":"Habbabe","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-2845","authenticated-orcid":false,"given":"Vivek Babu","family":"Nooney","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5536-1565","authenticated-orcid":false,"given":"Vincent","family":"Chan","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Letts","sequence":"additional","affiliation":[{"name":"The Pharmacy Department The Royal Children's Hospital Melbourne  Parkville Vic Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-7187","authenticated-orcid":false,"given":"Thilini","family":"Thrimawithana","sequence":"additional","affiliation":[{"name":"Discipline of Pharmacy, School of Health and Biomedical Sciences, STEM College RMIT University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"G. 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