{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T13:04:03Z","timestamp":1784379843959,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005199","name":"Chinese Medicine Research Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2022ZB017"],"award-info":[{"award-number":["2022ZB017"]}],"id":[{"id":"10.13039\/501100005199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Genetic determinants are central to ulcerative colitis (UC) pathogenesis, yet their identification via single\u2010cell transcriptomics and clinical translation remains incomplete. We integrated GWAS\u2010eQTL data with UC\u2010related differentially expressed genes (DEGs) to screen causal genes, mapped them in single\u2010cell datasets, and prioritized Epoxide Hydrolase 2 (EPHX2) due to the key role of intestinal epithelial cells (IECs) in UC. Colitis mouse and in\u00a0vitro inflammation models were used to validate EPHX2 expression. Gene Set Enrichment Analysis (GSEA) and functional assays explored its role in mechanisms such as wound healing. EPHX2, a causal gene expressed across epithelial subpopulations, was significantly downregulated in colitis models and cytokine\u2010stimulated NCM460 cells. GSEA suggested its involvement in mucosal healing, and functional studies confirmed that EPHX2 deficiency impairs mucosal repair capacity. We propose that EPHX2 deficiency may compromise IEC\u2010mediated mucosal healing in UC. This work advances the understanding of genetic determinants in UC and highlights a potential therapeutic target for disease management.<\/jats:p>","DOI":"10.1111\/cts.70651","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:49:57Z","timestamp":1782200997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["EPHX2 Orchestrates Intestinal Epithelial Barrier Repair in Ulcerative Colitis: An Integrated Multi\u2010Omics and Experimental Study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5966-1165","authenticated-orcid":false,"given":"Tian","family":"Dai","sequence":"first","affiliation":[{"name":"School of Pharmacy Hangzhou Normal University  Hangzhou Zhejiang People's Republic of China"},{"name":"Otolaryngology &amp; Head and Neck Center, Cancer Center, Department of Head and Neck Surgery Zhejiang Provincial People's Hospital, Affiliated 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