{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:24:12Z","timestamp":1787408652466,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>NAT2<\/jats:italic>\n                    gene encodes N\u2010acetyltransferase 2, an enzyme critically involved in the biotransformation of numerous xenobiotics and aromatic amines, including isoniazid, a cornerstone drug in tuberculosis therapy. Genetic polymorphisms in\n                    <jats:italic>NAT2<\/jats:italic>\n                    lead to variable acetylation rates, clinically categorized as poor, intermediate, or rapid metabolizer phenotypes influencing drug efficacy and toxicity. This study aims to characterize the\n                    <jats:italic>NAT2<\/jats:italic>\n                    polymorphisms in 240 Moroccan individuals using pre\u2010existing clinical exome sequencing data. A total of fourteen variants were identified in the\n                    <jats:italic>NAT2<\/jats:italic>\n                    coding region, with the most frequent being c.341\u2009T&gt;C (50%), c.803G&gt;A (48.95%), c.481C&gt;T (48.33%), and c.282C&gt;T (29.16%). Diplotype\u2010based phenotype prediction showed that 148 individuals (61.67%) were poor metabolizers, 71 (29.58%) intermediate metabolizers, and 14 (5.83%) rapid metabolizers. Seven individuals could not be classified due to the presence of variants with unreported diplotype\u2013phenotype correlations. These findings provide a comprehensive pharmacogenetic profile of\n                    <jats:italic>NAT2<\/jats:italic>\n                    in the Moroccan population and support the implementation of diplotype\u2010guided isoniazid dosing strategies in tuberculosis\u2010endemic settings.\n                  <\/jats:p>","DOI":"10.1111\/cts.70670","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T06:23:59Z","timestamp":1785133439000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Landscape of\n                    <scp>\n                      <i>NAT2<\/i>\n                    <\/scp>\n                    in the Moroccan Population: Implications for Isoniazid Pharmacogenetics in Tuberculosis"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3373-2812","authenticated-orcid":false,"given":"Nada","family":"Benyahya","sequence":"first","affiliation":[{"name":"Department of Medical Genetics National Institute of Hygiene  Rabat Morocco"},{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-3826","authenticated-orcid":false,"given":"Mohsine\u2010Ali","family":"El\u2010Hamri","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics National Institute of Hygiene  Rabat Morocco"},{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"},{"name":"Physiology and Physiopathology Team, Genomic of Human Pathologies Research Centre Mohammed V University in Rabat  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-1872","authenticated-orcid":false,"given":"Jaber","family":"Lyahyai","sequence":"additional","affiliation":[{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-739X","authenticated-orcid":false,"given":"Ilham","family":"Ratbi","sequence":"additional","affiliation":[{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"},{"name":"Unity of Medical Genetics, Children's Hospital, Ibn Sina University Hospital Center, Faculty of Medicine and Pharmacy Mohammed V University of Rabat  Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4426-5898","authenticated-orcid":false,"given":"Imane","family":"Cherkaoui","sequence":"additional","affiliation":[{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"},{"name":"Unity of Medical Genetics, Children's Hospital, Ibn Sina University Hospital Center, Faculty of Medicine and Pharmacy Mohammed V University of Rabat  Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zineb","family":"Rchiad","sequence":"additional","affiliation":[{"name":"Genomics Platform, UM6P Corelab University Mohammed VI Polytechnique  Ben Guerir Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-5215","authenticated-orcid":false,"given":"Abdelaziz","family":"Sefiani","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics National Institute of Hygiene  Rabat Morocco"},{"name":"Research Team in Genomics and Molecular Epidemiology of Genetic Diseases, Genopath Centre, Faculty of Medicine and Pharmacy of Rabat University Mohammed V  Rabat Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.75740"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijtb.2023.08.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10072278"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2025.2470630"},{"key":"e_1_2_13_6_1","volume-title":"Genetic Polymorphisms of N\u2010Acetyl Transferase 2 and the Risk of Hepatotoxicity in Patients on Isoniazid Preventive Therapy at Kenyatta National Hospital","author":"Akumu R. 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