{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T16:29:28Z","timestamp":1787416168434,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Interleukin\u201040 (IL\u201040) is a recently identified cytokine primarily produced by activated B cells and implicated in immune regulation across several autoimmune diseases. Although B cell\u2013driven immune dysregulation plays a central role in systemic sclerosis (SSc), the circulating behavior and clinical relevance of IL\u201040 in this disease remain poorly defined. To characterize serum IL\u201040 levels in patients with SSc and to explore their associations with immunosuppressive treatment exposure, disease subsets, clinical manifestations, and disease activity. Serum IL\u201040 levels were measured by ELISA in 41 patients with SSc and 29 age\u2010 and sex\u2010matched healthy controls. Patients were stratified according to immunosuppressive treatment status at the time of serum sampling. Clinical features, organ involvement, and disease activity were recorded. Serum IL\u201040 levels differed significantly among immunosuppressed SSc patients, untreated SSc patients, and healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patients receiving immunosuppressive therapy exhibited markedly lower IL\u201040 concentrations compared with both untreated SSc patients and healthy controls. In contrast, untreated SSc patients showed IL\u201040 levels comparable to controls. Serum IL\u201040 levels were not significantly associated with cutaneous disease subtype, interstitial lung disease, dysphagia, or disease activity status. Stratified analyses demonstrated that lower IL\u201040 levels in treated patients were observed irrespective of disease activity. Lower circulating IL\u201040 levels were observed in immunosuppressed patients irrespective of disease phenotype, organ involvement, or disease activity. These findings support an association between treatment exposure and circulating IL\u201040 levels, although longitudinal studies are needed to clarify causality.\n                  <\/jats:p>","DOI":"10.1111\/cts.70678","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T06:32:47Z","timestamp":1785047567000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interleukin\u201040 in Systemic Sclerosis: A Treatment\u2010Sensitive Marker of Immune Modulation Rather Than Disease Activity"],"prefix":"10.1111","volume":"19","author":[{"given":"\u0130brahim","family":"Vasi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emin \u00dcmit","family":"Ba\u011fr\u0131a\u00e7\u0131k","sequence":"additional","affiliation":[{"name":"Department of Immunology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0131za Can","family":"Karda\u015f","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-4000","authenticated-orcid":false,"given":"Nihan","family":"\u00d6r\u00fckl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Immunology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melek","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Immunology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2771-7725","authenticated-orcid":false,"given":"Derya","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcug\u00fcl","family":"Kaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahime","family":"Duran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Karaduman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-9519","authenticated-orcid":false,"given":"\u0130brahim Yahya","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamit","family":"K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna","family":"G\u00f6ker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsamet","family":"Erden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Akif","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology Gazi University, Faculty of Medicine  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002696"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30933-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.20506\/rst.17.1.1094"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700534"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.745523"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002738"},{"issue":"5","key":"e_1_2_9_8_1","first-page":"609","article-title":"Serum Interleukin 40: An Innovative Diagnostic Biomarker for Patients With Systemic Lupus Erythematosus","volume":"78","author":"Al Rubaye A. 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