{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:24:07Z","timestamp":1787408647927,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    ST\u2010segment elevation myocardial infarction (STEMI) remains a major cause of cardiovascular mortality and morbidity worldwide. Despite advances in reperfusion therapy, many patients still develop irreversible myocardial injury and adverse ventricular remodeling. Intracoronary mesenchymal stem cell (MSC) administration has been investigated as a potential therapeutic approach, but clinical evidence remains inconsistent. We performed a systematic review and meta\u2010analysis of randomized controlled trials (RCTs) comparing intracoronary MSC administration with standard care in STEMI patients. Databases were searched from inception through February 2026. Eight RCTs involving 796 patients were identified, and seven trials with 400 patients were included in the quantitative analysis after excluding one study under Expression of Concern. MSC administration significantly improved \u0394LVEF (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200944.6%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.108; WMD\u2009=\u20093.18, 95% CI: 1.52\u20134.83,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No significant differences were detected in rehospitalization for heart failure (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.592; RR\u2009=\u20091.14, 95% CI: 0.36\u20133.61,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.831), all\u2010cause mortality (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.525; RR\u2009=\u20091.51, 95% CI: 0.24\u20139.31,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.659), or MACE (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.887; RR\u2009=\u20092.47, 95% CI: 0.55\u201311.05,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.236). Intracoronary MSC administration after STEMI is associated with a modest improvement in left ventricular function, while no reduction in clinical events was found. No major safety signal was identified, although available safety data remain limited. Larger and well\u2010designed trials with longer follow\u2010up are still needed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO: CRD420261286620\n                  <\/jats:p>","DOI":"10.1111\/cts.70682","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:06:40Z","timestamp":1784963200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Intracoronary Mesenchymal Stem Cell Administration in\n                    <scp>ST<\/scp>\n                    \u2010Segment Elevation Acute Myocardial Infarction: A Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6049-6219","authenticated-orcid":false,"given":"Kaiming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiology Central Hospital Affiliated to Shenyang Medical College  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5034-6067","authenticated-orcid":false,"given":"Shijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Cardiology First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4443-0512","authenticated-orcid":false,"given":"Xiaoqian","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Central Hospital Affiliated to Shenyang Medical College  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8507-8891","authenticated-orcid":false,"given":"Zhaoshuang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Central Hospital Affiliated to Shenyang Medical College  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9625-6048","authenticated-orcid":false,"given":"Shuyue","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Central Hospital Affiliated to Shenyang Medical College  Shenyang 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