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This retrospective study included newly diagnosed patients receiving rituximab\u2010containing induction regimens. Blood samples were collected before the next dose and after completion of the current dose across different chemotherapy cycles during the induction therapy; plasma concentrations were measured by chemiluminescent immunoassay. A nonlinear mixed\u2010effects model was developed and externally validated. Individual parameters were obtained using empirical Bayesian methods, and first\u2010cycle trough concentrations were predicted. For model building, 45 patients and 115 samples were included; external validation used 12 patients and 28 samples. Rituximab pharmacokinetics were described by a two\u2010compartment model. Representative estimates were: clearance 0.0181\u2009L\/h, central volume 8.12\u2009L, intercompartmental clearance 0.0213\u2009L\/h, peripheral volume 29.2\u2009L. Albumin\u2010globulin ratio was the final covariate and significantly affected clearance. Validation indicated good stability and predictive performance. Predicted first\u2010cycle trough concentrations were below the reference efficacy threshold, and lower troughs were associated with smaller albumin\u2010globulin ratios. This model quantified the effect of albumin\u2010globulin ratio on clearance and suggests a risk of insufficient rituximab exposure during induction therapy, supporting future individualized dosing and therapeutic drug monitoring.<\/jats:p>","DOI":"10.1111\/cts.70683","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:32:47Z","timestamp":1784964767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Population Pharmacokinetics of Rituximab in Treatment\u2010Na\u00efve Chinese Patients With Diffuse Large B\u2010cell Lymphoma During Induction Therapy: Clinical Implications"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0045-4015","authenticated-orcid":false,"given":"Wan\u2010Yi","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Third Affiliated Hospital of Soochow University  Changzhou Jiangsu 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