{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T14:24:08Z","timestamp":1787408648028,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Drug\u2010induced QTc prolongation (diQTP) is a major risk factor for torsades de pointes and sudden cardiac death. This study evaluated whether carriers of the G allele of the\n                    <jats:italic>NOS1AP<\/jats:italic>\n                    rs10494366 T\u2009&gt;\u2009G variant have greater risk for diQTP when prescribed high\u2010risk QT\u2010prolonging medications. A retrospective case\u2010control analysis was conducted using the Michigan Genomics Initiative (MGI) biobank, linking genotype and electronic health records for 5848 patients of European ancestry prescribed \u2265\u20091 CredibleMeds high\u2010risk drug for torsades de pointes between 2001 and 2022. QTc was Bazett\u2010corrected, and diQTP was defined as change of &gt;\u200960\u2009ms from the baseline QTc and\/or QTc \u2265\u2009500\u2009ms. Associations between rs10494366 and diQTP were tested using unadjusted and propensity\u2010score\u2010adjusted logistic regression. The minor\u2010allele frequency (G) was 0.36, and genotype frequencies were in Hardy\u2013Weinberg equilibrium (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.07). diQTP occurred in 12.2% of participants. The G allele was not significantly associated with risk of diQTP in either the unadjusted analysis (OR 0.94 [95% CI 0.84\u20131.05]\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.27) or the adjusted analysis (OR 0.94 [95% CI 0.83\u20131.06]\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.30). In this large, real\u2010world cohort of patients with European ancestry, the\n                    <jats:italic>NOS1AP<\/jats:italic>\n                    rs10494366 variant was not significantly associated with the risk of diQTP. These findings suggest that previously observed associations between this variant and baseline QTc may not extend to all drug\u2010induced settings.\n                  <\/jats:p>","DOI":"10.1111\/cts.70698","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:45:08Z","timestamp":1786337108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the\n                    <i>NOS1AP<\/i>\n                    rs10494366 Genetic Variant With Drug\u2010Induced\n                    <scp>QT<\/scp>\n                    Prolongation"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5342-7364","authenticated-orcid":false,"given":"Christina A.","family":"Pippis","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-7158","authenticated-orcid":false,"given":"Ana I.","family":"Lopez\u2010Medina","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-8827","authenticated-orcid":false,"given":"Choudhary Anwar A.","family":"Chahal","sequence":"additional","affiliation":[{"name":"Center for Inherited Cardiovascular Diseases WellSpan Health  Lancaster Pennsylvania USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Cardiology Barts Heart Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3639-717X","authenticated-orcid":false,"given":"Jasmine A.","family":"Luzum","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2022-0027"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"37","article-title":"NOS1AP Modulates Intracellular Ca2+ in Cardiac Myocytes and Is Up\u2010Regulated in Dystrophic Cardiomyopathy","volume":"6","author":"Treuer A. V.","year":"2014","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.12.065"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.676783"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1365"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e328324e556"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-021-00256-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.16130"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1811-7241"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000336"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03325.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.031"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12050835"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12405"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2010.11.003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493400"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2023.100257"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs-2023-0229"},{"key":"e_1_2_11_20_1","volume-title":"QTdrugs List [Internet]","author":"Woosley R. L."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2015.05.003"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3656"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2025.154091"}],"container-title":["Clinical and Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70698","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cts.70698","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cts.70698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T13:38:22Z","timestamp":1787405902000},"score":1,"resource":{"primary":{"URL":"https:\/\/ascpt.onlinelibrary.wiley.com\/doi\/10.1111\/cts.70698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":22,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/cts.70698"],"URL":"https:\/\/doi.org\/10.1111\/cts.70698","archive":["Portico"],"relation":{},"ISSN":["1752-8054","1752-8062"],"issn-type":[{"value":"1752-8054","type":"print"},{"value":"1752-8062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70698"}}