{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:13Z","timestamp":1789996213666,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In July 2025, the Food and Drug Administration (FDA) warned of significant weight loss among young children receiving stimulants for attention\u2010deficit hyperactivity disorder. However, real\u2010world evidence on the magnitude and prevalence of stimulant\u2010associated weight loss remains limited. This study evaluated short\u2010term weight changes after methylphenidate initiation among youth aged 3\u201318\u2009years using the Medical record Observation and Assessment of drug safety Common Data Model (MOA CDM) in Korea. We conducted a retrospective study using electronic health record\u2010based MOA CDM data from January 2008 to December 2024. The cohort included individuals aged 3\u201318\u2009years with at least one methylphenidate prescription and had available weight measurements. The index date was defined as the first prescription date. Individuals without weight data within 45\u2009days before or 90\u2009days after the index date were excluded. Outcomes included changes in body weight (kg) and weight percentile, and the proportion having a \u2265\u200910\u2010percentile decline. Weight percentiles were calculated using the 2017 Korean National Growth Charts for Children and Adolescents. A total of 2087 youths from 17 nationwide hospitals were included; 68.71% were male, and 58.12% were aged 6\u201310\u2009years. Within 3\u2009months, mean body weight decreased by \u22120.33\u2009kg (95% confidence interval [CI], \u22120.44 to \u22120.22) and mean weight percentile decreased by \u22122.49 percentiles (95% CI, \u22122.83 to \u22122.15). Overall, 21.57% had a \u2265\u200910 percentile decline, with larger reductions among pre\u2010school\u2010aged children (28.57%). Our findings underscores the importance of growth monitoring during treatment initiation.<\/jats:p>","DOI":"10.1111\/cts.70709","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T03:58:48Z","timestamp":1787543928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Evidence on Short\u2010Term Weight Changes Following Methylphenidate Use in Pediatric Population: A Retrospective Study Using Common Data Model"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8111-4664","authenticated-orcid":false,"given":"Haeyoung","family":"Lee","sequence":"first","affiliation":[{"name":"Korea Institute of Drug Safety &amp; Risk Management  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-9584","authenticated-orcid":false,"given":"Eun\u2010Gee","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Institute of Drug Safety &amp; Risk Management  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-4300","authenticated-orcid":false,"given":"Hyeon\u2010Jong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Soonchunhyang University Seoul Hospital Soonchunhyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-1741","authenticated-orcid":false,"given":"Young\u2010Gyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Hallym University Sacred Heart Hospital  Anyang Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-2633","authenticated-orcid":false,"given":"Dong Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Ulsan University Hospital University of Ulsan College of Medicine  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Big Data Center Ulsan University Hospital  Ulsan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-0720","authenticated-orcid":false,"given":"Da Woon","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Chonnam National University Hospital Chonnam National University Medical School  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jewon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Medical Information Chonnam National University Hospital  Gwangju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2572-5302","authenticated-orcid":false,"given":"Sae\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7116-9052","authenticated-orcid":false,"given":"Dosang","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Medicine Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-5062","authenticated-orcid":false,"given":"Kwangsoo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Transdisciplinary Medicine Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Center for Data Science, Healthcare AI Research Institute Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9368-3896","authenticated-orcid":false,"given":"Jinsu","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Healthcare AI Research Support, Healthcare AI Research Institute Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-0693","authenticated-orcid":false,"given":"Yeesuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kounseok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-2962","authenticated-orcid":false,"given":"Hye\u2010Kyung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Pusan National University Hospital Pusan National University School of Medicine  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1846-8464","authenticated-orcid":false,"given":"Hyung Joon","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Korea University Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-9411","authenticated-orcid":false,"given":"In Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0286-2638","authenticated-orcid":false,"given":"Tai Joon","family":"An","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2799-4570","authenticated-orcid":false,"given":"Mi Hyoung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-2278","authenticated-orcid":false,"given":"Chaiho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Uijeongbu St. Mary's Hospital The Catholic University of Korea  Uijeongbu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-4911","authenticated-orcid":false,"given":"Sun","family":"Im","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea  Bucheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-5784","authenticated-orcid":false,"given":"Sung Woo","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-4447","authenticated-orcid":false,"given":"Jun Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, College of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14207338"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2025.101556"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019\u20102528"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009885.pub3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215\u20100366(18)30269\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272\u20107358(02)00129\u20100"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2021.03.019"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2021.0309"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010025\u201000728\u2010z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922820902437"},{"key":"e_1_2_10_12_1","unstructured":"\u201cExtended\u2010Release 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