{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:37Z","timestamp":1789996237367,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM008562"],"award-info":[{"award-number":["T32GM008562"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite the lack of evidence of a mechanism\u2010based drug interaction, some professional organizations have advised caution coadministering apixaban and levetiracetam. Eligible patients taking apixaban with or without levetiracetam for any indication for at least 72\u2009h were screened from the electronic medical records. Plasma samples from 77 patients were retrieved from salvaged clinical blood collections. Apixaban minimum and maximum concentrations (\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    and\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    ) were compared using descriptive statistics in R. While the median\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>min<\/jats:sub>\n                    and\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    appear to be marginally elevated, there were no apparent differences relative to apixaban alone. These findings suggest no apparent interaction of levetiracetam and support the current lack of labeled warning of concomitant apixaban dosing.\n                  <\/jats:p>","DOI":"10.1111\/cts.70719","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:25:08Z","timestamp":1788323108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Observational Study of the Effect of Concomitant Levetiracetam on Apixaban Concentrations in a Hospital Cohort"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6435-7611","authenticated-orcid":false,"given":"Chazmyn","family":"Riley","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Physiology, and Cancer Biology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-613X","authenticated-orcid":false,"given":"Kevin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology, and Cancer Biology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Micale","sequence":"additional","affiliation":[{"name":"Sidney Kimmel Medical College Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Thomson","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thomas Jefferson University Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2033-4943","authenticated-orcid":false,"given":"Douglas F.","family":"Stickle","sequence":"additional","affiliation":[{"name":"Department of Pathology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-0141","authenticated-orcid":false,"given":"Walter K.","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Physiology, and Cancer Biology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010023\u201000990\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2369"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010022\u201000971\u20109"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005398.pub4"},{"key":"e_1_2_9_6_1","unstructured":"UCB Inc. \u201cKEPPRA (Levetiracetam)\u201d[Package Insert] (2024)."},{"key":"e_1_2_9_7_1","unstructured":"National Health Service Specialist Pharmacy Service \u201cManaging Interactions With Direct Oral Anticoagulants (DOACs) \u201daccessed February 25 2026 https:\/\/www.sps.nhs.uk\/articles\/managing\u2010interactions\u2010with\u2010direct\u2010oral\u2010anticoagulants\u2010doacs\/#:~:text=and%20valproate%2Dcontaining\u2010 Show Management%20options."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euab065"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201033876\u20108"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010023\u201006992\u20106"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvz035"},{"key":"e_1_2_9_12_1","unstructured":"Bristol\u2010Myers Squibb \u201cEliquis (Apixaban)\u201d[Package Insert] (2025)."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010019\u201000775\u2010z"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.70392"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1505665"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2057"},{"issue":"10","key":"e_1_2_9_17_1","article-title":"Measurement of Plasma Apixaban by LC\u2010MS\/MS Using the AB Sciex API 3200MD","volume":"62","author":"Korn W. 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