{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:10:09Z","timestamp":1789996209527,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype is a known predictor of tacrolimus dose requirements. This single\u2010center retrospective study evaluated the impact of\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype\u2010guided dosing, implemented at our institution in 10\/2023, on early tacrolimus exposure. Patients were included if they were adult kidney transplant recipients between 7\/2014 and 10\/2024; patients in the weight\u2010based cohort had research\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotypes in the institutional research biorepository and the genotype\u2010guided cohort had a clinical\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype available at transplant. The primary outcome was time to therapeutic steady\u2010state (TSS) and secondary outcomes included classification of trough concentration on postoperative\u2010day (POD) 2, tacrolimus dose at TSS, and tacrolimus intrapatient variability (IPV) at 14\u2010 and 30\u2010day post\u2010transplant. Outcomes were also evaluated within each CYP3A5 phenotype and a per\u2010protocol evaluation. Outcomes were compared via Mann\u2013Whitney U, Chi\u2010squared, or Fischer's exact tests. The median TSS was decreased in CYP3A5 normal metabolizers (6.0\u2009days (3.0\u20136.0) vs. 16.0\u2009days (8.0\u201316.0);\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and CYP3A5 intermediate metabolizers had significantly fewer subtherapeutic troughs on POD2 (25.8% vs. 61.1%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) in the genotype\u2010guided cohort. CYP3A5 poor metabolizers were more likely to have a subtherapeutic trough on POD2 in the genotype\u2010guided cohort. The time below therapeutic range in the first 14\u2009days was significantly reduced for CYP3A5 intermediate metabolizers who received per\u2010protocol, genotype\u2010guided dosing. The TSS dose did not differ between the cohorts but was lower than the genotype\u2010guided protocol dosing.\n                    <jats:italic>CYP3A5<\/jats:italic>\n                    genotype\u2010guided dosing reduced the likelihood of early subtherapeutic exposure in CYP3A5 normal and intermediate metabolizers. Refinement of the genotype\u2010guided dosing strategy may help further improve early tacrolimus exposure.\n                  <\/jats:p>","DOI":"10.1111\/cts.70726","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:41:03Z","timestamp":1789587663000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differences in Early Tacrolimus Exposure in Kidney Transplant Recipients With and Without\n                    <scp>\n                      <i>CYP3A5<\/i>\n                    <\/scp>\n                    Genotype\u2010Guided Tacrolimus Dosing"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-5498","authenticated-orcid":false,"given":"Amy L.","family":"Pasternak","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"},{"name":"Department of Pharmacy Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett","family":"Vanderwerff","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Z\u00f6llner","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle J.","family":"Haakinson","sequence":"additional","affiliation":[{"name":"Department of Surgery Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Doshi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong M.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Michigan College of Pharmacy  Ann Arbor Michigan USA"},{"name":"Department of Pharmacy Michigan Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912023412303"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03188-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000640"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.113"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2010.17"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13691"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13980"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13059"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/PGPM.S285444"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-018-0750-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14893"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1656392"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002913"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2022.09.013"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2025.2549395"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02912"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13424"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2019.04.019"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11216320"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/tau-2025-456"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.70363"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14622416.2025.2489920"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.2249"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaf215"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/iyaf088"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2023.100257"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2601"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000000656"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0000000000001359"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000000644"},{"issue":"12","key":"e_1_2_10_33_1","first-page":"1454","article-title":"The 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