{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:50:05Z","timestamp":1792173005445,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["ascpt.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Translational Sci"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Controlled ovarian hyperstimulation (COH) is a precision medicine challenge, with substantial inter\u2010individual variability in ovarian response affecting treatment efficacy and safety during in\u00a0vitro fertilization (IVF). Clinical decision support (CDS) tools incorporating statistical, machine learning, and artificial intelligence approaches have been developed to individualize gonadotropin dosing and ovulation trigger timing. Therefore, this study aims to identify and evaluate CDS tools informing prescribing decisions during COH. Following PRISMA\u2010ScR guidance, Embase, MEDLINE, PubMed, and Scopus were searched from inception to March 2026. Studies evaluating CDS tools informing COH dosing and\/or ovulation trigger timing during IVF were included, stratified by predictive domain and analyzed descriptively. Primary outcomes were oocyte yield and metaphase II (MII) oocyte yield. Secondary outcomes included gonadotropin use and pregnancy\u2010related outcomes. Of 2879 records identified, five studies (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916,441) were included. One study reported precision\u2010dosing CDS tools that were associated with increased MII oocyte yield (1.5 oocytes,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and reduced gonadotropin use (195\u2009IU,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) compared with clinician\u2010directed dosing. A trigger\u2010timing model improved MII oocyte yield (2.5 oocytes,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), whereas combined dosing\u2010and\u2010trigger models demonstrated inconsistent effects. K\u2010nearest neighbor (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093) and linear regression (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093) approaches predominated. No pregnancy\u2010related outcomes were reported. No clinically evaluated mechanistic pharmacokinetic\/pharmacodynamic models were identified. CDS tools show promise for individualizing COH and improving treatment efficiency through precision dosing. However, clinical translation remains limited by a small and heterogeneous evidence base, reliance on surrogate outcomes, and lack of mechanistic model\u2010informed approaches. Prospective studies evaluating clinically meaningful outcomes are required to establish the role of CDS tools in personalized reproductive medicine.\n                  <\/jats:p>","DOI":"10.1111\/cts.70742","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:52:06Z","timestamp":1792050726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Decision Support Models to Optimize Controlled Ovarian Hyperstimulation: A Scoping Review"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2865-4422","authenticated-orcid":false,"given":"Robin Z. Y.","family":"Lu","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6422-8683","authenticated-orcid":false,"given":"Toni J. F.","family":"Michael","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-3671","authenticated-orcid":false,"given":"Vinayak","family":"Smith","sequence":"additional","affiliation":[{"name":"Virtus Health Pty Ltd.  Melbourne Victoria Australia"},{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-3994","authenticated-orcid":false,"given":"Beverley J.","family":"Vollenhoven","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Obstetrics &amp; Gynaecology Monash University  Melbourne Victoria Australia"},{"name":"Monash IVF  Melbourne Victoria Australia"},{"name":"Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-587X","authenticated-orcid":false,"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"},{"name":"Virtus Health Pty Ltd.  Melbourne Victoria Australia"},{"name":"School of Clinical Medicine, Faculty of Medicine and Health, St. Vincent's Healthcare Clinical Campus University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St. Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"100","volume-title":"Assisted Reproductive Technology in Australia and New Zealand 2023","author":"Kotevski D. 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