{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:15:34Z","timestamp":1783487734460,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>Spitz nevus is a benign melanocytic proliferation that shows relatively characteristic clinicopathologic features. Despite this, Spitz nevus is clinically confused with many other lesions, and histopathologically it is sometimes difficult to distinguish it from melanoma. However, Spitz nevus rarely causes differential diagnostic problems with granulomatous dermatitis. This article describes an 8\u2010year\u2010old girl who presented with a nodule on her right arm, a clinical appearance of a pyogenic granuloma. Histopathologically, there was a dermal lesion composed of aggregates of large epithelioid cells surrounded by a heavy inflammatory infiltrate, mimicking a sarcoid\u2010like granulomatous dermatitis. Immunohistochemistry showed epithelioid cells with strong nuclear and cytoplasmic staining with <jats:styled-content style=\"fixed-case\">S\u2010100<\/jats:styled-content> protein, thus establishing the diagnosis of a melanocytic tumor. The heavy T\u2010cell lymphocytic infiltrate that accompanies the large epithelioid cells caused its granulomatous appearance. Molecular assessment showed <jats:styled-content style=\"fixed-case\">H27H<\/jats:styled-content> mutation in the <jats:italic><jats:styled-content style=\"fixed-case\">HRAS<\/jats:styled-content><\/jats:italic> gene. We suggest the term \u2018pseudogranulomatous\u2019 for this variant of Spitz nevus because it indicates that the lesion is not authentically granulomatous and simply mimics a granulomatous dermatitis.<\/jats:p>","DOI":"10.1111\/cup.12011","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T03:49:14Z","timestamp":1347940154000},"page":"330-335","source":"Crossref","is-referenced-by-count":11,"title":["Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis"],"prefix":"10.1111","volume":"40","author":[{"given":"Vicente","family":"Sabater Marco","sequence":"first","affiliation":[{"name":"Department of Pathology University General Hospital  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Escutia Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital La Fe  Valencia 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