{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:18:35Z","timestamp":1778617115214,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T00:00:00Z","timestamp":1350086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>)\u2010infected patients carry an increased risk of lymphomagenesis. Although the majority of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related lymphomas have a B\u2010cell phenotype, the incidence of peripheral T\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>), including primary cutaneous subtypes, may be up to 15\u2010fold higher than in the general population, with anaplastic large cell lymphomas (<jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>) accounting for 18\u201328% of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>. In contrast to systemic <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>, the relation between <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection and primary cutaneous <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content> has been relatively neglected in the literature. We report the case of a primary cutaneous <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content> occurring in a 76\u2010year\u2010old patient with advanced <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection, and showing unusually aggressive course. Neither <jats:styled-content style=\"fixed-case\">ALK1<\/jats:styled-content> immunohistochemical positivity nor evidence of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> infection were detected; staging procedures at initial presentation ruled out systemic involvement. We provide a summary of the literature regarding primary cutaneous <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected patients. We draw attention to clinicopathological features, prognostic implications and therapeutic quandaries of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010related primary cutaneous <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>. Further, we propose that a significant fraction of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010associated cases might represent a more aggressive subset of primary cutaneous <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cup.12020","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T13:21:44Z","timestamp":1350134504000},"page":"1100-1109","source":"Crossref","is-referenced-by-count":17,"title":["<scp>HIV<\/scp>\u2010associated primary cutaneous anaplastic large cell lymphoma: a\u00a0clinicopathological subset with more aggressive behavior? Case report and review of the literature"],"prefix":"10.1111","volume":"39","author":[{"given":"Andrea","family":"Saggini","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Anemona","sequence":"additional","affiliation":[{"name":"Institute of Anatomic Pathology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Chimenti","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Sarmati","sequence":"additional","affiliation":[{"name":"Clinical Infectious Diseases University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Torti","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Di Stefani","sequence":"additional","affiliation":[{"name":"Institute of Anatomic Pathology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome Tor Vergata  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.8252"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328329216a"},{"key":"e_1_2_5_4_1","unstructured":"WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV\u2010related disease in adults and children.Geneva Switzerland:World Health Organization 2007:48."},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25903"},{"key":"e_1_2_5_6_1","first-page":"19","article-title":"Images in HIV\/AIDS. 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