{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:41Z","timestamp":1772160101749,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Inherent to some immunobullous disorders is potential for intraepidermal or dermal\u2013epidermal junction fragility, a phenomenon that may compromise biopsy specimen integrity and direct immunofluorescence (DIF)  interpretation. In these situations, cutaneous adnexal structures (e.g. hair follicles, sweat apparatus) usually remain intact. Whether periadnexal\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      findings are reliable in diagnosing immunobullous conditions is unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated 56 cutaneous specimens with diagnostic immunoglobulin (Ig) deposition patterns that contained adnexal structures. In a corollary study, we examined 145 hematoxylin\u2010eosin\u2010stained frozen specimens to determine biopsy factors associated with the presence of adnexal structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Periadnexal\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      findings offered diagnostic sensitivity in conditions with linear or cell\u2010surface Ig deposition or lupus band. Periadnexal\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      findings were unreliable in dermatitis herpetiformis. Biopsy specimens from scalp and genitalia were most likely to contain folliculosebaceous units and sweat duct apparatus, respectively. Relative depth of biopsy correlated directly with the likelihood of identifying sweat duct apparatus but not folliculosebaceous units.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Periadnexal\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      findings may add diagnostic sensitivity in\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      evaluation of pemphigoid, pemphigus and lupus erythematosus. Pathologists can guide clinicians to biopsy certain anatomic sites and to obtain sufficient biopsy depth to increase the probability of capturing adnexal structures and, therefore, diagnostic yield from\n                      <jats:styled-content style=\"fixed-case\">DIF<\/jats:styled-content>\n                      specimens.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cup.12037","type":"journal-article","created":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T06:21:22Z","timestamp":1351750882000},"page":"230-235","source":"Crossref","is-referenced-by-count":15,"title":["Diagnostic utility of direct immunofluorescence findings around hair follicles and sweat glands in immunobullous disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Julia S.","family":"Lehman","sequence":"first","affiliation":[{"name":"Department of Dermatology, Division of Anatomic Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Camilleri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Division of Anatomic Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1684\/ejd.2011.1310","article-title":"Antibodies to pilosebaceous units along their neurovascular supply routes in a new variant of endemic pemphigus foliaceus in Colombia, South America","volume":"21","author":"Abreu\u2010Velez AM","year":"2011","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4297\/najms.2010.2540"},{"key":"e_1_2_6_4_1","first-page":"48","article-title":"IgG bullous pemphigoid with antibodies to IgD, dermal blood vessels, eccrine glands and the endomysium of monkey esophagus","volume":"2","author":"Abreu\u2010Velez AM","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.007"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0972-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2009.05.009"},{"key":"e_1_2_6_8_1","first-page":"175","article-title":"Skin appendageal immune reactivity in a case of cutaneous lupus","volume":"2","author":"Abreu\u2010Velez AM","year":"2011","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.00993.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12515907"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0625.2002.120402.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02665.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23479.x"},{"issue":"17","key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1242\/jcs.111.17.2529","article-title":"Desmoglein 3 anchors telogen hair in the follicle","volume":"111","author":"Koch PJ","year":"1998","journal-title":"J Cell Sci"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.037"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011299"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240609"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01132.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcup.12037","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cup.12037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T12:40:47Z","timestamp":1700656847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cup.12037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["10.1111\/cup.12037"],"URL":"https:\/\/doi.org\/10.1111\/cup.12037","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717970498.793469171","asserted-by":"object"}]},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}