{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T15:19:46Z","timestamp":1785683986212,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>A 63\u2010year\u2010old man presented with an ulcerated nodule with a rolled pearly edge on his back. A punch biopsy showed diffuse strong <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression and retraction artifact. Consequently the tumor was diagnosed as a basal cell carcinoma but on excision the tumor proved to be a porocarcinoma. Although Jimenez et al. reported <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression in porocarcinoma, this result is not widely appreciated. This observation prompted us to investigate <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression in sweat apparatus tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Immunocytochemistry was performed using Dako monoclonal mouse <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> with Ventana Benchmark <jats:styled-content style=\"fixed-case\">XT<\/jats:styled-content> immunostainer. Omission of the primary antibody served as a negative control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen of 26 porocarcinomas had at least focal <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression and two were diffusely and at least focally strongly positive. Seven of seven chondroid syringomas stained diffusely positive, with strong ductal expression; the single chondroid syringocarcinoma was negative. Five of 6 poromas and two of two hidradenomas had focal expression, and staining particularly highlighted the ducts, a co\u2010localization also apparent in the four spiradenomas and three cylindromas. The single primary mucinous carcinoma had diffuse strong <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This case and pilot study shows that <jats:styled-content style=\"fixed-case\">BerEP4<\/jats:styled-content> expression is common in these selected sweat apparatus tumors, and staining may be strongly so. This observation should be borne in mind in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cup.12043","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T19:29:31Z","timestamp":1349983771000},"page":"259-264","source":"Crossref","is-referenced-by-count":11,"title":["<scp>BerEP4<\/scp> is widely expressed in tumors of the sweat apparatus: a source of potential diagnostic error"],"prefix":"10.1111","volume":"40","author":[{"given":"Maryam","family":"Afshar","sequence":"first","affiliation":[{"name":"The Medical School King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Deroide","sequence":"additional","affiliation":[{"name":"Department of Histopathology Royal Free Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Robson","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology St John's Institute of 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