{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:21:24Z","timestamp":1778872884848,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Clear cell sarcoma (<jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content>) of tendons and aponeuroses, also known as melanoma of soft parts, represents an aggressive rare malignancy that is characterized by a nested or fascicular pattern of spindled cells and a pathognomonic reciprocal translocation, t(12;22)(q13;q12), that results in the fusion of <jats:italic><jats:styled-content style=\"fixed-case\">EWSR1<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">ATF1<\/jats:styled-content><\/jats:italic> genes. Numerous recent studies have recognized the importance of a cutaneous CCS variant that can mimic a broad spectrum of entities, including spindle cell melanoma, spindle cell squamous carcinoma, cutaneous leiomyosarcoma and atypical fibroxanthoma. We report a case of a 13\u2010year\u2010old boy with cutaneous <jats:styled-content style=\"fixed-case\">CCS<\/jats:styled-content> who presented with a few months history of an asymptomatic papule on the lower lip that was suggestive of a mucocele. Biopsy of the lesion showed a wedge shaped neoplasm arranged in nests and fascicles of epithelioid\u2010 to oval\u2010shaped cells with pale cytoplasm, open chromatin and prominent nucleolus. The superficial component was closely opposed to the basal epithelium resembling the junctional nests of a melanocytic neoplasm. The process extended into and involved the striated muscle of the lip. The cells expressed S\u2010100, <jats:styled-content style=\"fixed-case\">CD99<\/jats:styled-content> and synaptophysin by immunohistochemistry, and there was focal <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 and microphthalmia transcription factor (MiTF) positivity as well. Fluorescence <jats:italic>in situ<\/jats:italic> hybridization confirmed the presence of the t(12;22) (<jats:italic><jats:styled-content style=\"fixed-case\">ESWR1\u2010ATF1<\/jats:styled-content><\/jats:italic>) translocation.<\/jats:p>","DOI":"10.1111\/cup.12058","type":"journal-article","created":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T18:16:11Z","timestamp":1352312171000},"page":"265-268","source":"Crossref","is-referenced-by-count":20,"title":["Superficial paramucosal clear cell sarcoma of the soft parts resembling melanoma in a 13\u2010year\u2010old boy"],"prefix":"10.1111","volume":"40","author":[{"given":"Michael","family":"Sidiropoulos","sequence":"first","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine Northwestern University  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Busam","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan\u2010Kettering Cancer Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Guitart","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine Northwestern University  Chicago IL USA"},{"name":"Robert H. Lurie Cancer Center, Feinberg School of Medicine Northwestern University  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William B.","family":"Laskin","sequence":"additional","affiliation":[{"name":"Robert H. Lurie Cancer Center, Feinberg School of Medicine Northwestern University  Chicago IL USA"},{"name":"Department of Pathology, Feinberg School of Medicine Northwestern University  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette M.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine Northwestern University  Chicago IL USA"},{"name":"Division of Dermatology, Children's Memorial Hospital Northwestern University  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedram","family":"Gerami","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Feinberg School of Medicine Northwestern University  Chicago IL USA"},{"name":"Robert H. Lurie Cancer Center, Feinberg School of Medicine Northwestern University  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196509)18:9<1163::AID-CNCR2820180916>3.0.CO;2-0"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198307000-00003"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990915)86:6<969::AID-CNCR11>3.0.CO;2-Z"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22380"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199212000-00006"},{"key":"e_1_2_4_7_1","first-page":"298","article-title":"Clear cell soft tissue sarcoma. 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