{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:01:10Z","timestamp":1766268070321},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma and extranodal natural killer (NK)\/T\u2010cell lymphoma (ENKTL<\/jats:styled-content>), nasal type are two distinct lymphoma entities in the World Health Organization (WHO<\/jats:styled-content>) classification. We report the case of an aggressive cutaneous lymphoma of \u03b3\u03b4 T\u2010cell origin showing overlapping features of both lymphomas. A 78\u2010year\u2010old female presented with confluent erythematous plaques with ulcerations over her right thigh. Microscopically, section of the skin showed a diffuse dermal and subcutaneous lymphocytic infiltration with tumor necrosis and angioinvasion. The medium\u2010 to large\u2010sized tumor cells expressed CD3<\/jats:styled-content>, CD8<\/jats:styled-content>, cytotoxic molecules and T\u2010cell receptor (TCR<\/jats:styled-content>)\u2010\u03b3 but not CD4<\/jats:styled-content>, CD20<\/jats:styled-content>, CD30<\/jats:styled-content>, CD56<\/jats:styled-content> or \u03b2F1<\/jats:styled-content>. In situ<\/jats:italic> hybridization for Epstein\u2010Barr virus\u2010encoded mRNA<\/jats:styled-content> (EBER) was diffusely positive. Polymerase chain reaction\u2010based clonality assay showed a clonal TCR<\/jats:styled-content>\u2010\u03b3 chain gene rearrangement. The features compatible with \u03b3\u03b4 T\u2010cell lymphoma include dermal and subcutaneous involvements, cytotoxic phenotype, expression of TCR<\/jats:styled-content>\u2010\u03b3, as well as an aggressive course. On the other hand, the diffuse EBER<\/jats:styled-content> positivity, angioinvasion, tumor necrosis and cytotoxic phenotype may also fit in the diagnosis of an ENKTL<\/jats:styled-content> of T\u2010cell lineage. We review the literature on EBER<\/jats:styled-content>\u2010positive \u03b3\u03b4 T\u2010cell lymphoma and discuss the diagnostic dilemma using the current WHO<\/jats:styled-content> classification system.<\/jats:p>","DOI":"10.1111\/cup.12066","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T23:36:46Z","timestamp":1354145806000},"page":"310-316","source":"Crossref","is-referenced-by-count":24,"title":["Cutaneous EBV<\/scp>\u2010positive \u03b3\u03b4 T\u2010cell lymphoma vs. extranodal NK<\/scp>\/T\u2010cell lymphoma: a case report and literature review"],"prefix":"10.1111","volume":"40","author":[{"given":"Wei\u2010Wen","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin\u2010Pen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Center for General Education Yuh\u2010Ing Junior College of Health Care and Management Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Sung","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Pathology Chi\u2010Mei Medical Center Tainan Taiwan"},{"name":"Department of Pathology Taipei Medical University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"302","volume-title":"WHO classification of tumours of haemtopoietic and lymphoid tissues","author":"Gaulard 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