{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:36:13Z","timestamp":1780349773197,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T00:00:00Z","timestamp":1355443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2013,3]]},"abstract":"Mycosis fungoides (MF<\/jats:styled-content>) represents the most common type of cutaneous lymphoma. MF<\/jats:styled-content> shows varieties in both its clinical presentation and immunophenotype. We herein report one case of poikilodermatous MF<\/jats:styled-content> with a CD8<\/jats:styled-content>+ CD56<\/jats:styled-content>+ immunophenotype and present a literature review. A 20\u2010year\u2010old Japanese woman presented with a 10\u2010year history of multiple poikilodermatous and reddish or brownish patches with mild pruritus on the chest, abdomen, back, buttock and thighs. Histopathologically, small\u2010 to medium\u2010sized atypical lymphocytes infiltrated into the epidermis, indicating epidermotropism, along the basal layer, and distributed in band\u2010like appearance in the papillary dermis. Immunohistochemically, atypical lymphocytes expressed CD3<\/jats:styled-content>, CD8<\/jats:styled-content>, CD56<\/jats:styled-content>, T\u2010cell intracellular antigen (TIA)\u20101, granzyme B and beta F1<\/jats:styled-content> but lacked expression of CD4<\/jats:styled-content>, CD20<\/jats:styled-content>, CD30<\/jats:styled-content> and Epstein\u2010Barr virus (EBV<\/jats:styled-content>) latent membrane protein 1. An EBV<\/jats:styled-content>\u2010encoded small non\u2010polyadenylated RNA<\/jats:styled-content>\u20101 (EBER\u20101) signal was not detected. On the basis of these findings, the diagnosis of CD8<\/jats:styled-content>+ CD56<\/jats:styled-content>+ MF<\/jats:styled-content> was established. Poikilodermatous MF<\/jats:styled-content> with a CD8<\/jats:styled-content>+ CD56<\/jats:styled-content>+ immunophenotype, as presented herein, is extremely rare. Although further investigation is needed to fully clarify the nature of this aberrant phenotype of MF<\/jats:styled-content>, we stress that it is important to recognize this rare immunophenotype of MF<\/jats:styled-content> to distinguish it from aggressive cytotoxic cutaneous lymphomas.<\/jats:p>","DOI":"10.1111\/cup.12067","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T23:33:06Z","timestamp":1354145586000},"page":"317-320","source":"Crossref","is-referenced-by-count":24,"title":["Poikilodermatous mycosis fungoides with a CD8<\/scp>+ CD56<\/scp>+ immunophenotype: a case report and literature review"],"prefix":"10.1111","volume":"40","author":[{"given":"Tatsushi","family":"Shiomi","sequence":"first","affiliation":[{"name":"Department of Pathology, Kawasaki Medical School Kawasaki Hospital Okayama Japan"},{"name":"Department of Pathology Kawasaki Medical School Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Monobe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kawasaki Medical School Kawasaki Hospital Okayama Japan"},{"name":"Department of Pathology Kawasaki Medical School Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kawasaki Medical School Kawasaki Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruko","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kawasaki Medical School Kawasaki Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takenobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kawasaki Medical School Kawasaki Hospital Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Sadahira","sequence":"additional","affiliation":[{"name":"Department of Pathology Kawasaki Medical School Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09301.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.01.133"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/9781444316742.ch6","volume-title":"Skin lymphoma. 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